US 12,134,626 B2
Ferrocene derivative, preparation method therefor and use thereof
Jianping Yong, Fujian (CN); and Canzhong Lu, Fujian (CN)
Assigned to XIAMEN INSTITUTE OF RARE EARTH MATERIALS, Xiamen (CN)
Appl. No. 17/289,714
Filed by XIAMEN INSTITUTE OF RARE-EARTH MATERIALS, Fujian (CN)
PCT Filed Feb. 24, 2021, PCT No. PCT/CN2021/077608
§ 371(c)(1), (2) Date Apr. 28, 2021,
PCT Pub. No. WO2022/178701, PCT Pub. Date Sep. 1, 2022.
Prior Publication US 2022/0356199 A1, Nov. 10, 2022
Int. Cl. C07F 17/02 (2006.01); A61P 35/00 (2006.01)
CPC C07F 17/02 (2013.01) [A61P 35/00 (2018.01)] 18 Claims
 
1. A ferrocene derivative of formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof:

OG Complex Work Unit Chemistry
wherein Z is selected from NH, O and S;
R1 is selected from hydrogen, methyl, F and Cl;
R2 is independently selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 haloalkyl and nitro; and
n is an integer from 0 to 5.