	US 12,134,607 B2
	Crystals of tetrahydronaphthyl urea derivative
Yuji Kawada, Tokyo (JP); Fumihiko Saitoh, Tokyo (JP); Hiroshi Nagasue, Tokyo (JP); and Tsutomu Satoh, Tokyo (JP)
Assigned to MOCHIDA PHARMACEUTICAL CO., LTD., Tokyo (JP)
Filed by MOCHIDA PHARMACEUTICAL CO., LTD., Tokyo (JP)
Filed on Apr. 1, 2022, as Appl. No. 17/711,876.
Application 17/711,876 is a continuation of application No. 16/647,223, granted, now 11,325,895, previously published as PCT/JP2018/034021, filed on Sep. 13, 2018.
Claims priority of application No. 2017-178030 (JP), filed on Sep. 15, 2017.
Prior Publication US 2022/0348552 A1, Nov. 3, 2022
Int. Cl. C07D 401/04 (2006.01)

CPC C07D 401/04 (2013.01) [C07B 2200/13 (2013.01)]

10 Claims

1. A type V crystal of 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(2-methylpyrimidin-5-yl)-2-phenylpyridin-3-yl) urea having characteristic peaks at least at diffraction angles (2θ) of 7.2±0.2, 10.8±0.2, 11.9±0.2, 14.5±0.2, 18.8±0.2, 22.3±0.2, 23.9±0.2, 24.2±0.2, 26.0±0.2 and 27.9±0.2) (°) in x-ray powder diffraction.