	US 12,134,604 B1
	1-[4,5-bis(4-chlorophenyl)-1-hexyl-1H-imidazol-2-yl]-2-naphthol as an antimicrobial compound
Hany Mohamed Abd El-Lateef Ahmed, Al-Ahsa (SA); Mai Mostafa Khalaf Ali, Al-Ahsa (SA); and Antar Ahmed Abdelhamid Ahmed, Sohag (EG)
Assigned to KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed by KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed on May 13, 2024, as Appl. No. 18/662,706.
Application 18/662,706 is a division of application No. 18/503,823, filed on Nov. 7, 2023, granted, now 12,017,999.
Int. Cl. C07D 233/64 (2006.01); A61P 31/04 (2006.01); A61P 31/10 (2006.01)

CPC C07D 233/64 (2013.01) [A61P 31/04 (2018.01); A61P 31/10 (2018.01)]

2 Claims

1. A method of making a 1-[4,5-bis(4-chlorophenyl)-1-hexyl 1H-imidazol-2-yl]-2-naphthol compound, the method comprising:

mixing 4,4′-dichlorobenzil, 2-hydroxy-1-naphthaldehyde, hexylamine, and ammonium acetate in pyridinium hydrogen sulfate to obtain a solution;

heating the solution in an oil bath, wherein the oil bath is about 120° C. and the solution is heated for about 5 minutes;

washing the solution and isolating yields in the solution using methyl alcohol; and

obtaining the 1-[4,5-bis(4-chlorophenyl)-1-hexyl-1H-imidazol-2-yl]-2-naphthol compound,

wherein the pyridinium hydrogen sulfate is at about 25° C.; and

wherein the molar ratio of 4,4′-dichlorobenzil, 2-hydroxy-1-naphthaldehyde, hexylamine, and ammonium acetate are added in about a 1:1:1:1 molar ratio.