US 12,133,991 B2
Computer-implemented method for radiotherapy treatment planning, computer program product and computer system for performing the method
Bjorn Andersson, Uppsala (SE); Erik Engwall, Hagersten (SE); Albin Fredriksson, Stockholm (SE); and Kjell Eriksson, Balsta (SE)
Assigned to Raysearch Laboratories AB (publ), Stockholm (SE)
Appl. No. 17/907,543
Filed by RAYSEARCH LABORATORIES AB, Stockholm (SE)
PCT Filed Mar. 22, 2021, PCT No. PCT/EP2021/057259
§ 371(c)(1), (2) Date Sep. 28, 2022,
PCT Pub. No. WO2021/197895, PCT Pub. Date Oct. 7, 2021.
Claims priority of application No. 20167803 (EP), filed on Apr. 2, 2020.
Prior Publication US 2023/0141197 A1, May 11, 2023
Int. Cl. A61N 5/10 (2006.01)
CPC A61N 5/1038 (2013.01) [A61N 5/1039 (2013.01); A61N 5/1001 (2013.01); A61N 2005/1087 (2013.01); A61N 2005/1089 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A computer-based method of optimizing a radiotherapy treatment plan for delivering radiotherapy to a patient by means of a second radiation set, comprising the steps of
a) determining, based on at least a first medical image of the patient, a dose previously delivered to the patient by means of a first radiation set,
b) obtaining a first optimization problem comprising an optimization function designed to optimize the dose distribution resulting from the second radiation set in dependence of dose criteria set for a total dose and of the previously delivered dose, the total dose being the dose resulting from the second radiation set and the previously delivered radiation set,
c) optimizing the treatment plan for delivering radiotherapy by the second radiation set by means of the optimization problem, wherein the optimization function is an objective function or a constraint and one of the first and the second radiation set is brachytherapy and the other is external beam radiation therapy.