US 12,133,921 B2
Capsule filling composition, method of producing capsule formulation with the use of capsule filling composition, and capsule formulation
Takafumi Hoshino, Yokohama (JP)
Assigned to SHIN-ETSU CHEMICAL CO., LTD., Tokyo (JP)
Filed by SHIN-ETSU CHEMICAL CO., LTD., Tokyo (JP)
Filed on Oct. 28, 2020, as Appl. No. 17/082,042.
Claims priority of application No. 2019-196189 (JP), filed on Oct. 29, 2019.
Prior Publication US 2021/0121409 A1, Apr. 29, 2021
Int. Cl. A61K 9/48 (2006.01); A61J 3/07 (2006.01); A61K 47/38 (2006.01)
CPC A61K 9/4833 (2013.01) [A61J 3/074 (2013.01); A61K 9/4808 (2013.01); A61K 9/4866 (2013.01); A61K 47/38 (2013.01)] 6 Claims
 
1. A method of producing a capsule formulation, comprising dry blending a raw material comprising an active ingredient and a cellulose ether powder to obtain a capsule filling composition comprising the active ingredient and the cellulose ether powder; subjecting the capsule filling composition to a funnel system powder filling or a die-compression system powder filling to prepare a compressed product; and filling a capsule container with the compressed product to obtain the capsule formulation,
wherein the funnel system powder filling comprises pushing a funnel for filling into a powder layer and compressing the powder to prepare a compressed product, and then transferring the compressed product into a capsule body;
the die-compression system powder filling comprises introducing a powder into a molding plate, compressing the powder with a tapping rod to prepare a compressed product, and then scraping off excess powder followed by transferring the compressed product into a capsule body; and
wherein the capsule formulation comprises a capsule filling composition containing an active ingredient, a cellulose ether powder and an additive agent, wherein the content of the cellulose ether powder is in the range between 0.01 parts by weight and 20 parts by weight relative to 1 part by weight of the active ingredient.