	US 12,133,919 B2
	Stabilized microcapsules, method of their preparation and uses thereof
Ofer Toledano, Kfar Saba (IL); Karine Neimann, Ness Ziona (IL); Danil Finkel-Moiseev, Rehovot (IL); Maya Erlich, Ness Ziona (IL); and Dorit Marco, Rehovot (IL)
Assigned to Sol-Gel Technologies Ltd., Ness Ziona (IL)
Filed by Sol-Gel Technologies Ltd., Ness Ziona (IL)
Filed on May 23, 2021, as Appl. No. 17/327,729.
Claims priority of provisional application 63/028,599, filed on May 22, 2020.
Prior Publication US 2021/0361608 A1, Nov. 25, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/48 (2006.01); A61K 9/00 (2006.01); A61K 9/50 (2006.01); A61K 31/202 (2006.01); A61K 31/203 (2006.01); A61K 31/235 (2006.01); A61K 31/327 (2006.01); A61K 31/336 (2006.01)

CPC A61K 9/4808 (2013.01) [A61K 9/0014 (2013.01); A61K 9/4841 (2013.01); A61K 9/4858 (2013.01); A61K 9/4875 (2013.01); A61K 9/501 (2013.01); A61K 9/5084 (2013.01); A61K 9/5089 (2013.01); A61K 31/202 (2013.01); A61K 31/203 (2013.01); A61K 31/235 (2013.01); A61K 31/327 (2013.01); A61K 31/336 (2013.01)]

9 Claims

1. A pharmaceutical composition comprising a microcapsule comprising a core encapsulated by a shell, wherein said core comprises tretinoin or pharmaceutically acceptable salt thereof in a solid form and wherein the microencapsulation efficiency of the tretinoin or pharmaceutically acceptable salt thereof is at least 90%.