US 12,133,915 B2
Method of treating epilepsy
James Cassella, Essex, CT (US); Lily Gong, San Jose, CA (US); and Edwin S. Kamemoto, Redwood City, CA (US)
Assigned to ALEXZA PHARMACEUTICALS, INC., Mountain View, CA (US)
Filed by ALEXZA PHARMACEUTICALS, INC., Mountain View, CA (US)
Filed on Apr. 14, 2022, as Appl. No. 17/721,183.
Application 17/721,183 is a continuation of application No. 17/244,963, filed on Apr. 30, 2021, granted, now 11,717,479.
Application 17/244,963 is a continuation of application No. 16/469,143, granted, now 11,241,383, issued on Jan. 19, 2022, previously published as PCT/US2017/065347, filed on Dec. 8, 2017.
Claims priority of provisional application 62/432,353, filed on Dec. 9, 2016.
Claims priority of provisional application 62/485,281, filed on Apr. 13, 2017.
Prior Publication US 2022/0241191 A1, Aug. 4, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 31/5517 (2006.01); A61P 25/08 (2006.01)
CPC A61K 9/0073 (2013.01) [A61K 9/16 (2013.01); A61K 31/5517 (2013.01); A61P 25/08 (2018.01)] 34 Claims
OG exemplary drawing
 
1. A method for stopping an ongoing seizure in a subject in need thereof,
the method comprising administering alprazolam via a breath-activated inhalation device during the ongoing seizure which has not progressed to status epilepticus, wherein the alprazolam is administered in a dose of about 1 mg to about 2 mg, wherein the inhalation device comprises:
a first element for rapidly heating a heat-conductive, impermeable substrate coated with an alprazolam composition to form a vapor;
a second element allowing the vapor to cool, thereby providing a condensation aerosol comprising alprazolam particles, and
a third element permitting inhalation of the condensation aerosol;
and
whereby the ongoing seizure is stopped within 2 minutes of inhalation of alprazolam.