US 12,133,909 B2
Use of evodone or a derivative thereof as a cooling agent
Anthony Pegard, Grasse (FR); Sophie Lavoine, Mouans Sartoux (FR); and Marina Humbert, Grasse (FR)
Assigned to ROBERTET S.A., Grasse (FR)
Appl. No. 17/433,087
Filed by ROBERTET S.A., Grasse (FR)
PCT Filed Feb. 21, 2020, PCT No. PCT/FR2020/050326
§ 371(c)(1), (2) Date Aug. 23, 2021,
PCT Pub. No. WO2020/169935, PCT Pub. Date Aug. 27, 2020.
Claims priority of application No. 19/01805 (FR), filed on Feb. 22, 2019.
Prior Publication US 2022/0040077 A1, Feb. 10, 2022
Int. Cl. A61K 8/49 (2006.01)
CPC A61K 8/4973 (2013.01) [A61K 2800/244 (2013.01)] 10 Claims
 
1. A method for causing a cold thermal effect comprising applying an effective amount onto the skin or into the oral cavity of a human subject in need of or desirous of a cold thermal effect, a cooling agent of general formula (I)

OG Complex Work Unit Chemistry
in which:
R1 and R2 are chosen independently of each other as a hydrogen atom or a C1-C6-alkyl group; and
X represents ═O,-OAc, —O—C1-C6-alkyl, —N—OH or —OH.