US 12,133,896 B2
Methods for treating or alleviating a bone-loss related disease or condition by administering a nucleic acid encoding a discoidin domain receptor 1 (DDR1) protein
Chau-Zen Wang, Kaohsiung (TW); Chung-Hwan Chen, Kaohsiung (TW); Liang-Yin Chou, Kaohsiung (TW); Yu Chou, Kaohsiung (TW); Mei-Ling Ho, Kaohsiung (TW); and Yi-Hsiung Lin, Kaohsiung (TW)
Assigned to KAOHSIUNG MEDICAL UNIVERSITY, Kaohsiung (TW)
Filed by Kaohsiung Medical University, Kaohsiung (TW)
Filed on Feb. 5, 2021, as Appl. No. 17/168,873.
Application 17/168,873 is a continuation in part of application No. 16/496,666, granted, now 10,946,021, previously published as PCT/CN2018/080238, filed on Apr. 24, 2018.
Claims priority of provisional application 62/475,397, filed on Mar. 23, 2017.
Prior Publication US 2021/0162074 A1, Jun. 3, 2021
Int. Cl. A61K 48/00 (2006.01); A61K 9/00 (2006.01); A61K 9/127 (2006.01); A61K 35/76 (2015.01); A61K 38/45 (2006.01); A61P 19/00 (2006.01); A61P 19/10 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01)
CPC A61K 48/0058 (2013.01) [A61K 9/0019 (2013.01); A61K 9/127 (2013.01); A61K 38/45 (2013.01); A61K 48/0075 (2013.01); A61P 19/00 (2018.01); A61P 19/10 (2018.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 35/76 (2013.01); C12N 2740/15043 (2013.01)] 16 Claims
 
1. A method for treating or alleviating an osteoporosis in a subject, comprising:
identifying the subject having the osteoporosis; and
administering to the subject an effective amount of a composition that increases a level of Discoidin Domain Receptor 1 (DDR1) protein in bone or joints in the subject, wherein the composition comprises a nucleic acid encoding the DDR1 protein.