	US 12,133,890 B2
	Antigen-binding polypeptide targeting B7H3 and application thereof
Xiaoyun Shang, Ningbo (CN); Haijuan Jiang, Ningbo (CN); Dan Wang, Ningbo (CN); Jialu Li, Ningbo (CN); Shaowen Ma, Ningbo (CN); Hui Shen, Ningbo (CN); Li Ma, Ningbo (CN); and Weijie Chen, Ningbo (CN)
Assigned to NINGBO T-MAXIMUM BIOPHARMACEUTICALS CO., LTD., Ningbo (CN)
Appl. No. 18/575,650
Filed by NINGBO T-MAXIMUM BIOPHARMACEUTICALS CO., LTD., Ningbo (CN)
PCT Filed Jun. 30, 2022, PCT No. PCT/CN2022/103070 § 371(c)(1), (2) Date Dec. 29, 2023, PCT Pub. No. WO2023/274384, PCT Pub. Date Jan. 5, 2023.
Claims priority of application No. 202110749481.6 (CN), filed on Jul. 1, 2021.
Prior Publication US 2024/0269283 A1, Aug. 15, 2024
Int. Cl. A61K 39/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01)

CPC A61K 39/4643 (2023.05) [A61K 39/4611 (2023.05); A61K 39/4631 (2023.05); A61K 39/464411 (2023.05); A61K 39/464412 (2023.05); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70578 (2013.01); C07K 16/2827 (2013.01); C12N 5/0636 (2013.01); A61K 2239/26 (2023.05); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); C07K 2317/53 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C12N 2510/00 (2013.01)]

26 Claims

1. An antigen-binding polypeptide, binding B7H3, comprising an antibody heavy chain variable region (VH), wherein the VH comprises

i) an HCDR1 comprising the amino acid sequence set forth in SEQ ID NO: 2, an HCDR2 comprising the amino acid sequence set forth in SEQ ID NO: 5, and an HCDR3 comprising the amino acid sequence set forth in SEQ ID NO: 8; or

ii) an HCDR1 comprising the amino acid sequence set forth in SEQ ID NO: 3, an HCDR2comprising the amino acid sequence set forth in SEQ ID NO: 6, and an HCDR3 comprising the amino acid sequence set forth in SEQ ID NO: 9.