	US 12,133,889 B2
	Metal aluminum nano-adjuvant, vaccine composition and preparation method therefor and use thereof
Kun Liu, Changchun (CN); Hua Yu, Changchun (CN); Chenggong Yang, Changchun (CN); Tianmeng Sun, Changchun (CN); Ye Wang, Changchun (CN); and Ge Zhu, Changchun (CN)
Assigned to Jilin University, Changchun (CN)
Filed by Jilin University, Jilin (CN)
Filed on Apr. 25, 2022, as Appl. No. 17/728,382.
Prior Publication US 2023/0338518 A1, Oct. 26, 2023
Int. Cl. A61K 39/39 (2006.01); A61K 9/19 (2006.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01)

CPC A61K 39/39 (2013.01) [A61K 9/19 (2013.01); A61P 35/00 (2018.01); A61K 2039/53 (2013.01); A61K 2039/55505 (2013.01)]

18 Claims

1. A vaccine composition, wherein, the vaccine composition comprises the vaccine adjuvant, and an antigen or DNA encoding the antigen; wherein the vaccine adjuvant comprises metal aluminum nanoparticles, wherein the average particle size of the metal aluminum nanoparticles is 10-1000 nm, and wherein the metal aluminum nanoparticles are composed of a metal aluminum core with zero valent aluminum (Al⁰) and amorphous alumina layer with a thickness of 3-5 nm on the surface.