US 12,133,879 B2
Exosomes for target specific delivery and methods for preparing and delivering the same
Chulhee Choi, Daejeon (KR); Nambin Yim, Daejeon (KR); Hojun Choi, Daejeon (KR); Kyungsun Choi, Daejeon (KR); and Seung-Wook Ryu, Daejeon (KR)
Assigned to ILIAS BIOLOGICS INC., Daejeon (KR); and ILIAS THERAPEUTICS, INC., New York, NY (US)
Filed by ILIAS BIOLOGICS INC., Daejeon (KR); and ILIAS THERAPEUTICS, INC., New York, NY (US)
Filed on Jan. 12, 2024, as Appl. No. 18/412,403.
Application 18/412,403 is a continuation in part of application No. 16/887,029, filed on May 29, 2020, granted, now 11,872,193.
Application 18/412,403 is a continuation in part of application No. 16/639,740, abandoned, previously published as PCT/IB2018/056200, filed on Aug. 16, 2018.
Application 16/887,029 is a continuation of application No. 15/803,338, filed on Nov. 3, 2017.
Application 15/803,338 is a continuation in part of application No. PCT/KR2017/011070, filed on Sep. 30, 2017.
Application PCT/IB2018/056200 is a continuation in part of application No. PCT/KR2016/004750, filed on May 4, 2016.
Claims priority of provisional application 62/659,816, filed on Apr. 19, 2018.
Claims priority of application No. 10-2015-0062604 (KR), filed on May 4, 2015; application No. 10-2015-0120934 (KR), filed on Aug. 27, 2015; application No. 10-2016-0126335 (KR), filed on Sep. 30, 2016; application No. 10-2016-0126921 (KR), filed on Sep. 30, 2016; application No. 10-2016-0126961 (KR), filed on Sep. 30, 2016; application No. 10-2016-0127486 (KR), filed on Oct. 4, 2016; application No. 10-2016-0132616 (KR), filed on Oct. 13, 2016; application No. 10-2017-0018637 (KR), filed on Feb. 10, 2017; and application No. 10-2017-0104171 (KR), filed on Aug. 17, 2017.
Prior Publication US 2024/0207360 A1, Jun. 27, 2024
Int. Cl. A61K 47/69 (2017.01); A61K 38/17 (2006.01); C07K 14/705 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C12N 15/62 (2006.01); C12N 15/85 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01)
CPC A61K 38/177 (2013.01) [A61K 47/6917 (2017.08); C07K 14/705 (2013.01); C07K 14/70596 (2013.01); C07K 16/18 (2013.01); C07K 16/28 (2013.01); C12N 15/62 (2013.01); C12N 15/85 (2013.01); C12P 21/02 (2013.01); A61K 38/00 (2013.01); C07K 2317/80 (2013.01); C07K 2319/03 (2013.01); C07K 2319/70 (2013.01)] 16 Claims
 
1. An exosome comprising
a transmembrane protein, and
a target peptide inserted into an extracellular domain of the transmembrane protein.