US 12,133,861 B2
Nail compositions having antifungal properties
Corinne Jeanne Rose Granger, Barcelona (ES); and Carlos Ramon Trullas Cabanas, Barcelona (ES)
Assigned to ISDIN, S.A., Barcelona (ES)
Appl. No. 17/420,332
Filed by ISDIN, S.A., Barcelona (ES)
PCT Filed Jan. 7, 2020, PCT No. PCT/EP2020/050215
§ 371(c)(1), (2) Date Jul. 1, 2021,
PCT Pub. No. WO2020/144185, PCT Pub. Date Jul. 16, 2020.
Claims priority of application No. 19382010 (EP), filed on Jan. 8, 2019.
Prior Publication US 2022/0088060 A1, Mar. 24, 2022
Int. Cl. A61K 31/728 (2006.01); A61K 9/00 (2006.01); A61K 47/32 (2006.01); A61P 31/00 (2006.01)
CPC A61K 31/728 (2013.01) [A61K 9/0014 (2013.01); A61K 47/32 (2013.01); A61P 31/00 (2018.01)] 19 Claims
 
1. A combination comprising:
a) rhamnose or a rhamnose-rich polysaccharide, wherein the rhamnose-rich polysaccharide comprises rhamnose in an amount equal or higher than 30% w/w;
b) a film-forming agent;
c) an extract of Pistacia lentiscus; and
d) one or more further active agents selected from:
i) a hyaluronic acid derivative selected from the group consisting of hyaluronic acid, a pharmaceutically or cosmetically acceptable salt thereof, and a cationized hyaluronic acid, wherein the cationized hyaluronic acid is a hyaluronic acid wherein the hydrogen atom of at least one of the hydroxylic groups or the carboxylic group is replaced by a moiety of formula (III):

OG Complex Work Unit Chemistry
 wherein each of R1-R4 independently represents a linear or branched (C1-C6)alkyl group optionally substituted with one or more hydroxyl groups, and X is a halogen ion; and
ii) a silanol compound.