US 12,133,846 B2
Electrophilic androgen receptor (AR) antagonists for AR downregulation and ferroptosis induction in cancer cells
Zhihui Qin, Mundelein, IL (US); and Liping Xu, Detroit, MI (US)
Assigned to Wayne State University, Detroit, MI (US)
Filed by WAYNE STATE UNIVERSITY, Detroit, MI (US)
Filed on Oct. 15, 2020, as Appl. No. 17/071,896.
Claims priority of provisional application 62/915,500, filed on Oct. 15, 2019.
Prior Publication US 2021/0106571 A1, Apr. 15, 2021
Int. Cl. A61K 31/4439 (2006.01); A61K 31/198 (2006.01); A61K 47/54 (2017.01)
CPC A61K 31/4439 (2013.01) [A61K 31/198 (2013.01); A61K 47/54 (2017.08)] 10 Claims
 
1. An androgen receptor (AR) inhibitor of Formula II, III, IV, V, or a salt thereof:

OG Complex Work Unit Chemistry
wherein X is H or CN; and

OG Complex Work Unit Chemistry
wherein X═H, or CN; and Y═CH2, O, NH, or NCH3.