US 12,133,738 B2
Non-invasive topographic localization of glymphatic flow
Paul Dagum, Los Altos Hills, CA (US); and Laurent B. Giovangrandi, Palo Alto, CA (US)
Assigned to Applied Cognition, Inc., Redwood City, CA (US)
Filed by Applied Cognition, Inc., Los Altos Hills, CA (US)
Filed on Oct. 23, 2023, as Appl. No. 18/492,775.
Claims priority of provisional application 63/380,726, filed on Oct. 24, 2022.
Prior Publication US 2024/0130664 A1, Apr. 25, 2024
Prior Publication US 2024/0225523 A9, Jul. 11, 2024
Int. Cl. A61B 5/00 (2006.01); A61B 5/0536 (2021.01); A61B 5/256 (2021.01); A61M 21/02 (2006.01); A61N 1/05 (2006.01)
CPC A61B 5/4064 (2013.01) [A61B 5/0536 (2013.01); A61B 5/256 (2021.01); A61B 5/4088 (2013.01); A61B 5/6814 (2013.01); A61B 5/6817 (2013.01); A61M 21/02 (2013.01); A61N 1/0541 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A device for topographic localization of glymphatic flow, the device comprising:
a headcap configured to be worn on top of a head of a subject, the headcap comprising left electrodes and right electrodes, wherein the left electrodes and the right electrodes are multiplexed to gather passive EEG signals and responsive electrical potential data; and
a controller coupled to the headcap, the controller comprising a processor and a power source that are electrically coupled to the left electrodes and the right electrodes;
wherein at least one electrode of the left electrodes and the right electrodes is an input electrode that provides input currents over a range of frequencies that are generated by the power source and wherein other electrodes of the left electrodes and the right electrodes measure the responsive electrical potential data in response to the input currents, and
wherein the device is configured to provide an indication of a change in the glymphatic flow that is localized to the left electrodes and the right electrodes by deriving left impedance data and right impedance data from the responsive electrical potential data over time.