US 12,133,720 B2
Methods and compositions for restoring homeostatic capacity of a subject
Anthony Joonkyoo Yun, Menlo Park, CA (US); and Conrad Minkyoo Yun, San Mateo, CA (US)
Assigned to Palo Alto Investors LP, Palo Alto, CA (US)
Filed by Palo Alto Investors LP, Palo Alto, CA (US)
Filed on Oct. 1, 2020, as Appl. No. 17/060,769.
Application 17/060,769 is a continuation of application No. 14/737,248, filed on Jun. 11, 2015, granted, now 10,835,134.
Claims priority of provisional application 62/128,816, filed on Mar. 5, 2015.
Claims priority of provisional application 62/012,083, filed on Jun. 13, 2014.
Claims priority of provisional application 62/012,093, filed on Jun. 13, 2014.
Prior Publication US 2021/0076956 A1, Mar. 18, 2021
Int. Cl. A61B 5/024 (2006.01); A61B 5/00 (2006.01); A61B 5/16 (2006.01); A61K 31/00 (2006.01); A61K 45/06 (2006.01); A61N 1/05 (2006.01); A61N 1/36 (2006.01); G16H 20/00 (2018.01); G16H 50/30 (2018.01); A61B 5/021 (2006.01); A61B 5/352 (2021.01)
CPC A61B 5/02405 (2013.01) [A61B 5/165 (2013.01); A61B 5/4035 (2013.01); A61B 5/4848 (2013.01); A61B 5/7275 (2013.01); A61K 31/00 (2013.01); A61K 45/06 (2013.01); A61N 1/0551 (2013.01); A61N 1/36053 (2013.01); A61N 1/36139 (2013.01); G16H 20/00 (2018.01); G16H 50/30 (2018.01); A61B 5/021 (2013.01); A61B 5/024 (2013.01); A61B 5/352 (2021.01); A61B 5/4806 (2013.01); A61B 5/486 (2013.01); A61B 2505/09 (2013.01); A61N 1/36031 (2017.08); A61N 1/3606 (2013.01)] 16 Claims
 
1. A method of at least partially restoring homeostatic capacity of a subject, the method comprising:
modulating via an electrical protocol at least a portion of an autonomic nervous system of the subject in a manner sufficient to modulate a sympathetic/parasympathetic activity ratio of the subject and thereby at least partially restore the homeostatic capacity of the subject by applying electrical energy to at least a portion of a central nervous system endocrine gland of the subject, wherein the homeostatic capacity comprises an ability of the subject to self-stabilize in response to stressors; and
providing one or more holiday periods during which the application of the electrical energy to the subject is ceased and the subject is permitted to mount a compensatory response and thereby preventing a disease condition from happening, wherein:
the application of the electrical energy is in an irregularly irregular manner; and
a duration of the one or more holiday periods varies randomly over an entire course of a treatment.