US 12,463,026 B2
Machine difference correction method for mass spectrometry apparatus
Naoki Kaneko, Kyoto (JP); Tatsuki Okubo, Kyoto (JP); Tomonori Oshikawa, Kyoto (JP); Yuko Kobayashi, Kyoto (JP); Yoshiki Tainaka, Kyoto (JP); Kohei Suzuki, Kyoto (JP); and Takashi Nishikaze, Kyoto (JP)
Assigned to SHIMADZU CORPORATION, Kyoto (JP)
Appl. No. 18/019,626
Filed by Shimadzu Corporation, Kyoto (JP)
PCT Filed Jan. 6, 2021, PCT No. PCT/JP2021/000235
§ 371(c)(1), (2) Date Mar. 7, 2023,
PCT Pub. No. WO2022/030032, PCT Pub. Date Feb. 10, 2022.
Claims priority of provisional application 63/062,677, filed on Aug. 7, 2020.
Prior Publication US 2024/0266158 A1, Aug. 8, 2024
Int. Cl. H01J 49/00 (2006.01)
CPC H01J 49/0009 (2013.01) 13 Claims
OG exemplary drawing
 
1. A method for calibrating a difference in signal intensity ratio between machines in mass spectrometry, the method comprising the steps of:
measuring a calibrant containing not less than two calibration substances by a mass spectrometer to obtain a signal peak of each of the calibration substances;
determining a signal peak intensity ratio of, relative to a signal peak intensity of one calibration substance of the not less than two calibration substances, a signal peak intensity of another calibration substance;
determining a calibration formula from the signal peak intensity ratio;
measuring a sample containing not less than two analyte substances by the mass spectrometer to obtain a signal peak of each of the analyte substances;
determining a signal peak intensity ratio of, relative to a signal peak intensity of one analyte substance of the not less than two analyte substances, a signal peak intensity of another analyte substance; and
calibrating the signal peak intensity ratio of the analyte substances using the calibration formula.