US 12,462,939 B2
Atlas-based characterization of patent-specific cardiac electromechanical activation maps
Kevin Vincent, San Diego, CA (US); and Andrew D. McCulloch, San Diego, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Appl. No. 18/257,265
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Dec. 22, 2021, PCT No. PCT/US2021/064992
§ 371(c)(1), (2) Date Jun. 13, 2023,
PCT Pub. No. WO2022/140627, PCT Pub. Date Jun. 30, 2022.
Claims priority of provisional application 63/129,053, filed on Dec. 22, 2020.
Prior Publication US 2024/0047064 A1, Feb. 8, 2024
Int. Cl. G16H 50/20 (2018.01); A61B 5/319 (2021.01); A61B 5/341 (2021.01); A61B 5/367 (2021.01); G16H 20/40 (2018.01)
CPC G16H 50/20 (2018.01) [A61B 5/319 (2021.01); A61B 5/341 (2021.01); A61B 5/367 (2021.01); G16H 20/40 (2018.01)] 19 Claims
OG exemplary drawing
 
1. A system, comprising:
at least one processor; and
at least one memory including program code which when executed by the at least one processor provides operations comprising:
generating, based at least on a plurality of electrophysiology simulations, one or more atlases by at least applying a dimensionality reduction technique, the one or more atlases including an activation time atlas and a vectorcardiogram atlas, the one or more atlases further including one or more modes that capture variation present in the plurality of electrophysiology simulations, wherein the one or more modes of variation include a first mode associated with variations between an early activation on an anterior wall of a heart and a posterior wall of the heart, a second mode associated with variations in an apical and/or basal direction of the heart, and a third mode associated with variations in a right ventricle and left ventricle of the heart;
applying the one or more atlases to match a clinical vectorcardiogram of a patient to a simulated vectorcardiogram associated with an activation map included in the plurality of electrophysiology simulations; and
determining, based at least on the activation map, at least one of a diagnosis or treatment for the patient.