US 12,462,912 B2
System and method for physical activity informed drug dosing
Marc D. Breton, Charlottesville, VA (US); Stephen D. Patek, Charlottesville, VA (US); and Basak Ozaslan, Charlottesville, VA (US)
Assigned to The University of Virginia Licensing and Ventures Group, Charlottesville, VA (US)
Filed by The University of Virginia Licensing and Ventures Group, Charlottesville, VA (US)
Filed on Feb. 13, 2019, as Appl. No. 16/274,874.
Claims priority of provisional application 62/629,849, filed on Feb. 13, 2018.
Prior Publication US 2019/0252055 A1, Aug. 15, 2019
Int. Cl. G16H 20/10 (2018.01); G16H 10/40 (2018.01); G16H 10/60 (2018.01); G16H 20/60 (2018.01); G16H 50/30 (2018.01)
CPC G16H 20/10 (2018.01) [G16H 10/40 (2018.01); G16H 10/60 (2018.01); G16H 20/60 (2018.01); G16H 50/30 (2018.01)] 25 Claims
OG exemplary drawing
 
1. A method of adjusting insulin bolus for optimized control of a computer-implemented functional insulin treatment therapy by maintaining a low blood glucose (BG) variability, the method comprising:
quantifying physical activity (PA) of a patient;
calculating an accumulated PA based on the quantified PA, the accumulated PA indicating an aggregate of the PA that has an impact on blood glucose (BG) uptake for the patient;
generating a previous activity component based on an account of the accumulated PA over time period (t), the previous activity component including a band defined by a range of accumulated PA levels in which no PA-related insulin adjustment occurred during time period t;
at a time of a bolus decision:
adjusting a prevalent functional insulin therapy bolus using the previous activity component to generate an activity informed insulin bolus when accumulated PA for an activity component over time period (T) is outside the band of accumulated PA levels; and
generating a signal to cause an insulin delivery device to administer the activity informed insulin bolus to the patient;
wherein:
time period t includes a time that precedes a time in time period T; and
a timespan for time period t corresponds to a timespan for time period T.