US 12,461,119 B2
System and method for dispense characterization
Aaron Ewoniuk, Tucson, AZ (US); Dylan Miller, Tucson, AZ (US); and Kevin Talucci, Tucson, AZ (US)
Assigned to Ventana Medical Systems, Inc., Tucson, AZ (US)
Filed by Ventana Medical Systems, Inc., Tucson, AZ (US)
Filed on Mar. 11, 2024, as Appl. No. 18/601,690.
Application 18/601,690 is a continuation of application No. 17/326,760, filed on May 21, 2021, granted, now 11,959,931.
Application 17/326,760 is a continuation of application No. 16/112,438, filed on Aug. 24, 2018, granted, now 11,073,529, issued on Jul. 27, 2021.
Application 16/112,438 is a continuation of application No. PCT/US2017/019732, filed on Feb. 27, 2017.
Claims priority of provisional application 62/301,221, filed on Feb. 29, 2016.
Prior Publication US 2024/0329074 A1, Oct. 3, 2024
Int. Cl. G01N 35/10 (2006.01); B01L 3/02 (2006.01); G01F 15/075 (2006.01); G01F 22/00 (2006.01); G01N 1/31 (2006.01); G01N 15/14 (2006.01); G01N 35/00 (2006.01); G01N 15/10 (2006.01)
CPC G01N 35/1016 (2013.01) [B01L 3/0241 (2013.01); G01F 15/075 (2013.01); G01F 22/00 (2013.01); G01N 1/312 (2013.01); G01N 15/1459 (2013.01); G01N 35/00663 (2013.01); G01N 35/00722 (2013.01); G01N 35/1002 (2013.01); B01L 2200/061 (2013.01); B01L 2200/14 (2013.01); B01L 2200/143 (2013.01); G01N 2015/1027 (2024.01); G01N 2015/1493 (2013.01); G01N 2035/00673 (2013.01); G01N 2035/009 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for treating a biological sample, comprising:
a. at least one dispenser for dispensing a liquid reagent;
b. at least one dispense detector locatable between an outlet of the at least one dispenser and the biological sample, the dispense detector comprising at least one array of emitters and corresponding receivers, the space between the emitters and corresponding receivers of the at least one array forming a first detection region of the at least one dispense detector; and,
c. a dispense detection unit configured to receive a signal from the at least one dispense detector during one or more dispensing events and output a detected volume, shape, and/or velocity of the dispensed liquid reagent; and wherein the dispense detection unit is further configured to integrate, over time, a product of a velocity of the liquid reagent passing through the at least one dispense detector and the signal received from the at least one dispense detector, wherein the integrated signal provides a detected dispense volume for the liquid reagent dispensed from the at least one dispenser; and
d. a dispense error unit configured to compare the one or more detected dispense events to one or more predetermined corresponding expected characteristics of the liquid reagent.