US 12,461,078 B2
Compounds for use in system suitability testing of inert LC systems and columns
Amit Patel, Shrewsbury, MA (US); Matthew A. Lauber, North Smithfield, RI (US); Kevin Wyndham, Upton, MA (US); Mathew DeLano, Needham, MA (US); and Jennifer Simeone, Shrewsbury, MA (US)
Assigned to Waters Technologies Corporation, Milford, MA (US)
Filed by Waters Technologies Corporation, Milford, MA (US)
Filed on Sep. 10, 2021, as Appl. No. 17/471,463.
Claims priority of provisional application 63/079,151, filed on Sep. 16, 2020.
Claims priority of provisional application 63/079,160, filed on Sep. 16, 2020.
Prior Publication US 2022/0091079 A1, Mar. 24, 2022
Int. Cl. G01N 30/88 (2006.01); G01N 30/02 (2006.01)
CPC G01N 30/88 (2013.01) [G01N 2030/027 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A kit for evaluating liquid chromatography (LC) system and column inertness, the kit comprising:
a first vial comprising a positive control comprising a metal interacting moiety, wherein the positive control is selected from the group consisting of 2′(3′)-O-(4-Benzoylbenzoyl) adenosine 5′- triphosphate (Bz-ATP), ATP labeled with 6-aminohexyladenosine, ATP labeled with methylanthraniloyl, ATP labeled with trinitrophenyl, ATP labeled with fluorescein, and ATP labeled with pyrene; and
a second vial comprising a negative control comprising caffeine, the negative control not containing a metal interacting moiety, wherein both the positive control and the negative control are used as probe compounds for the detection of exposed metal in LC system and column.