US 12,461,050 B2
System and devices for monitoring cell-containing materials and methods of their use
Jared Matthews, Ithaca, NY (US); and Lawrence Bonassar, Ithaca, NY (US)
Assigned to CORNELL UNIVERSITY, Ithaca, NY (US)
Filed by CORNELL UNIVERSITY, Ithaca, NY (US)
Filed on May 21, 2024, as Appl. No. 18/669,910.
Application 18/669,910 is a continuation of application No. 17/039,234, filed on Sep. 30, 2020, granted, now 12,019,040.
Claims priority of provisional application 62/908,329, filed on Sep. 30, 2019.
Prior Publication US 2025/0020609 A1, Jan. 16, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 27/02 (2006.01); G01N 1/10 (2006.01); G01N 27/06 (2006.01)
CPC G01N 27/026 (2013.01) [G01N 27/06 (2013.01); G01N 2001/1012 (2013.01)] 28 Claims
OG exemplary drawing
 
1. A system for collecting or extruding a cell-containing biological material, said system comprising:
an extrusion/collection device comprising:
an orifice and
a chamber operably connected to the orifice and
an electrical impedance spectroscopy (EIS) device, operably connected to the extrusion/collection device;
wherein the EIS device monitors biologically relevant attributes of a cell-containing biological material as it is extruded from or collected into the extrusion/collection device, and wherein the extrusion/collection device is capable of any one or more of the following operations: varying the flow rate of the cell-containing biological material from or into the extrusion/collection device, varying the quantity of cells in the cell-containing biological material being extruded from or collected into the extrusion/collection device, and varying the pressure of the cell-containing biological material as it is extruded from or collected into the extrusion/collection device.