US 12,461,033 B2
Apparatus for performing photochemical measurements on a liquid or liquid-containing sample
Raja Chouket, Paris (FR); Agathe Espagne, Paris (FR); Ludovic Jullien, Paris (FR); Annie Lemarchand, Paris (FR); Thomas Le Saux, Paris (FR); Agnès Pellissier-Tanon, Paris (FR); Laurence Signon Colonna Bozzi, Grosseto Prugna (FR); and Ruikang Zhang, Paris (FR)
Assigned to CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); ECOLE NORMALE SUPERIEURE DE PARIS, Paris (FR); and SORBONNE UNIVERSITE, Paris (FR)
Appl. No. 17/768,463
Filed by CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); ECOLE NORMALE SUPERIEURE DE PARIS, Paris (FR); and SORBONNE UNIVERSITE, Paris (FR)
PCT Filed Jul. 31, 2020, PCT No. PCT/EP2020/071659
§ 371(c)(1), (2) Date Apr. 12, 2022,
PCT Pub. No. WO2021/078419, PCT Pub. Date Apr. 29, 2021.
Claims priority of application No. 19306385 (EP), filed on Oct. 24, 2019.
Prior Publication US 2023/0141123 A1, May 11, 2023
Int. Cl. G01N 21/64 (2006.01); G01N 21/65 (2006.01); G02B 21/08 (2006.01); G02B 21/16 (2006.01); G02B 27/14 (2006.01)
CPC G01N 21/6458 (2013.01) [G01N 21/65 (2013.01); G02B 21/08 (2013.01); G02B 21/16 (2013.01); G02B 27/141 (2013.01); G01N 2021/6419 (2013.01)] 15 Claims
OG exemplary drawing
 
1. An apparatus for performing photochemical measurements on a liquid or liquid-containing sample comprising: a light generating system, an optical system configured for directing light from the light generating system towards the sample, a processor configured or programmed for controlling the light generating system by modulating the light intensity values for illuminating the sample according to a predetermined illumination sequence and a sensing system for measuring at least one optical property of the sample, wherein:
the light generating system is configured for generating light at least one wavelength with an intensity level adjustable within a range spanning at least three and preferably at least five orders of magnitude; and
the optical system is configured for directing light from the light generating system towards the sample so as to generate a uniform light intensity level, with a tolerance of plus or minus 30%, preferably plus or minus 20% and even more preferably plus or minus 10%, within a cylindrical region of the sample having a height larger than or equal to five times its radius, said radius being of at least 3 μm,
wherein the illumination sequence comprises a plurality of subsequences, each subsequence comprising, in at least a part of the subsequence, illuminating the sample at the at least one wavelength with a constant intensity, the intensity values at said wavelength varying from one subsequence to the next.