	US 12,460,263 B2
	Genetic variants for diagnosis of Alzheimer's disease
Nancy Yuk-Yu Ip, Hong Kong (CN); Kit Yu Fu, Hong Kong (CN); Xiaopu Zhou, Chongqing (CN); Yuanbing Jiang, Sichuan (CN); Yu Chen, Hong Kong (CN); and Fanny Chui Fun Ip, Hong Kong (CN)
Assigned to The Hong Kong University of Science and Technology, Kowloon (HK)
Appl. No. 17/639,065
Filed by The Hong Kong University of Science and Technology, Kowloon (CN)
PCT Filed Aug. 25, 2020, PCT No. PCT/CN2020/111095 § 371(c)(1), (2) Date Feb. 28, 2022, PCT Pub. No. WO2021/037027, PCT Pub. Date Mar. 4, 2021.
Claims priority of provisional application 62/893,502, filed on Aug. 29, 2019.
Prior Publication US 2022/0325347 A1, Oct. 13, 2022
Int. Cl. C12Q 1/6883 (2018.01); A61K 31/496 (2006.01); A61K 45/06 (2006.01); A61P 25/28 (2006.01); G01N 33/68 (2006.01); C12Q 1/6869 (2018.01)

CPC C12Q 1/6883 (2013.01) [A61K 31/496 (2013.01); A61K 45/06 (2013.01); A61P 25/28 (2018.01); G01N 33/6896 (2013.01); C12Q 1/6869 (2013.01); C12Q 2600/156 (2013.01); G01N 2800/2821 (2013.01)]

18 Claims

1. A method for detecting the presence of Alzheimer's Disease (AD) or an increased risk of later developing AD in a subject, comprising the step of detecting in a biological sample taken from the subject the presence of genetic variants comprising rs1921622, rs75687525, rs4499395, rs56238602, rs2140316, rs12052753, rs199977663, rs2141304, rs4103380, rs4703514, rs191531802, rs2300619, rs1229502, rs9886235, rs6587006, rs7047059, rs5006678, rs7849649, rs1907370, rs11615704, rs66994203, rs117523785, rs17641976, rs7208104, rs12600563, rs142226688, rs111246464, rs4583526, and rs56242654.