US 12,460,216 B2
Phage-derived particles for in situ delivery of DNA payload into C. acnes population
Aymeric Leveau, Paris (FR); Inès Canadas Blasco, Paris (FR); Aurélie Mathieu, Paris (FR); and Antoine Decrulle, Paris (FR)
Assigned to Eligo Bioscience, Paris (FR)
Filed by Eligo Bioscience, Paris (FR)
Filed on Mar. 27, 2024, as Appl. No. 18/617,782.
Application 18/617,782 is a continuation of application No. 18/477,069, filed on Sep. 28, 2023, granted, now 11,970,701.
Application 18/477,069 is a continuation of application No. 17/518,936, filed on Nov. 4, 2021, granted, now 11,820,989, issued on Nov. 21, 2023.
Claims priority of provisional application 63/145,969, filed on Feb. 4, 2021.
Claims priority of provisional application 63/145,967, filed on Feb. 4, 2021.
Claims priority of provisional application 63/109,832, filed on Nov. 4, 2020.
Claims priority of provisional application 63/109,834, filed on Nov. 4, 2020.
Prior Publication US 2024/0254496 A1, Aug. 1, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 7/00 (2006.01); A61K 39/02 (2006.01); A61K 39/05 (2006.01); A61P 17/10 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12N 15/76 (2006.01); A61K 39/00 (2006.01); C12N 9/64 (2006.01)
CPC C12N 15/76 (2013.01) [A61K 39/02 (2013.01); A61K 39/05 (2013.01); A61P 17/10 (2018.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); A61K 2039/53 (2013.01); C12N 9/64 (2013.01); C12N 2310/20 (2017.05); C12N 2795/10343 (2013.01); C12N 2800/101 (2013.01); C12N 2800/80 (2013.01)] 17 Claims
 
1. A C. acnes phage-derived particle comprising a phagemid lacking genes encoding phage structural proteins, said phagemid comprising:
a phage packaging signal allowing packaging of the phagemid in a Cutibacterium acnes phage capsid,
wherein the phage packaging signal is at least 87% identical to SEQ ID NO: 76,
a gene of interest, and
a CRISPR-Cas system.