US 12,460,212 B2
Anti-microbial and UV-protective extracts and methods of making and using thereof
Raul Cuero Rengifo, Cypress, TX (US); and Juliana Londono Murillo, Manizales (CO)
Assigned to BIOCAPITAL HOLDINGS, LLC, Houston, TX (US)
Filed by BIOCAPITAL HOLDINGS, LLC, Houston, TX (US)
Filed on May 15, 2023, as Appl. No. 18/317,548.
Application 18/317,548 is a continuation of application No. 16/971,347, granted, now 11,692,192, previously published as PCT/US2019/019075, filed on Feb. 22, 2019.
Claims priority of provisional application 62/754,291, filed on Nov. 1, 2018.
Claims priority of provisional application 62/634,251, filed on Feb. 23, 2018.
Prior Publication US 2023/0340497 A1, Oct. 26, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 15/52 (2006.01); A01N 63/50 (2020.01); A61K 8/9728 (2017.01); A61K 8/99 (2017.01); C05F 11/00 (2006.01); C08G 18/32 (2006.01); C08G 18/76 (2006.01); C09D 5/16 (2006.01); C09D 5/32 (2006.01); C12N 9/02 (2006.01); C12N 9/04 (2006.01); C12N 9/20 (2006.01); C12N 15/62 (2006.01); C12N 15/81 (2006.01); C07K 14/405 (2006.01); C08G 101/00 (2006.01); C12N 9/64 (2006.01); C12N 15/70 (2006.01)
CPC C12N 15/52 (2013.01) [A01N 63/50 (2020.01); A61K 8/9728 (2017.08); A61K 8/99 (2013.01); C05F 11/00 (2013.01); C08G 18/3218 (2013.01); C08G 18/7671 (2013.01); C09D 5/1637 (2013.01); C09D 5/32 (2013.01); C12N 9/0006 (2013.01); C12N 9/0091 (2013.01); C12N 9/20 (2013.01); C12N 15/62 (2013.01); C12N 15/81 (2013.01); C12Y 101/01001 (2013.01); C07K 14/405 (2013.01); C07K 2319/00 (2013.01); C08G 2101/00 (2013.01); C12N 9/641 (2013.01); C12N 15/70 (2013.01)] 30 Claims
 
1. A DNA construct comprising the following genetic components: (a) a gene having SEQ ID NO: 1 or at least 90% homology thereto that encodes a zinc-related protein/oxidase, (b) a gene having SEQ ID NO: 2 or at least 90% homology thereto that encodes a silicatein, (c) a gene having SEQ ID NO: 3 or at least 90% homology thereto that encodes a silaffin, and (d) a gene having SEQ ID NO. 4 or at least 90% homology thereto that encodes an alcohol dehydrogenase II.