| CPC C07K 16/40 (2013.01) [A61K 49/0004 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] | 8 Claims |
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1. An isolated antibody or antigen binding fragment thereof that binds plasma kallikrein (pKal), wherein the isolated antibody comprises:
(i) a heavy chain immunoglobulin variable domain (VH) sequence comprising a heavy chain complementarity determining region (HC CDR) 1 sequence of PYNMY (SEQ ID NO: 121), a HC CDR2 sequence of SIRPSGGGTVYADSVKG (SEQ ID NO: 157), a HC CDR3 sequence of GFIAARWYYFDY (SEQ ID NO: 193), a light chain immunoglobulin variable domain (VL) sequence comprising a complementarity determining region (LC CDR) 1 sequence of RASQSVSSSYLA (SEQ ID NO: 13), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 49), and a LC CDR3 sequence of QQYGSSPFT (SEQ ID NO: 85);
(ii) a VH sequence comprising a HC CDR1 sequence of WYTMV (SEQ ID NO: 122), a HC CDR2 sequence of RIYPSGGWTKYADSVKG (SEQ ID NO: 158), a HC CDR3 sequence of EGLLWFGENAFDI (SEQ ID NO: 194), a VL comprising a LC CDR1 sequence of SGDQLGDKYVG (SEQ ID NO: 14), a LC CDR2 sequence of QDTKRPS (SEQ ID NO: 50), and a LC CDR3 sequence of QAWDTSTAG (SEQ ID NO: 86);
(iii) a VH sequence comprising a HC CDR1 sequence of WYLMI (SEQ ID NO: 123), a HC CDR2 sequence of YIYPSGGFTYYADSVKG (SEQ ID NO: 159), a HC CDR3 sequence of TEGPLSWGYGMDV (SEQ ID NO: 195), a VL comprising a LC CDR1 sequence of SGDKLGDKYAC (SEQ ID NO: 15), a LC CDR2 sequence of QDSKRPS (SEQ ID NO: 51), and a LC CDR3 sequence of QAWDSSTGV (SEQ ID NO: 87);
(iv) a VH sequence comprising a HC CDR1 sequence of WYTMV (SEQ ID NO: 124), a HC CDR2 sequence of RIYPSGGWTKYADSVKG (SEQ ID NO: 160), a HC CDR3 sequence of EGLLWFGENAFDI (SEQ ID NO: 197), a VL comprising a LC CDR1 sequence of SGDQLGDKYVG (SEQ ID NO: 16), a LC CDR2 sequence of QDTKRPS (SEQ ID NO: 52), and a LC CDR3 sequence of QAWDTSTAG (SEQ ID NO: 88);
(v) a VH sequence comprising a HC CDR1 sequence of WYEMG (SEQ ID NO: 126), a HC CDR2 sequence of SIYSSGGGTMYADSVKG (SEQ ID NO: 162), a HC CDR3 sequence of NPQYSGYDRSLSDGAFDI (SEQ ID NO: 198), a VL comprising a LC CDR1 sequence of SGDNLGNKYNS (SEQ ID NO: 18), a LC CDR2 sequence of QDTKRPS (SEQ ID NO: 54), and a LC CDR3 sequence of QAWDGNVV (SEQ ID NO: 90);
(vi) a VH sequence comprising a HC CDR1 sequence of YYMMV (SEQ ID NO: 128), a HC CDR2 sequence of YIYSSGGHTVYADSVKG (SEQ ID NO: 164), a HC CDR3 sequence of DLFLYDFWSKGAFDI (SEQ ID NO: 200), a LC CDR1 sequence of SGEKLGDKYVS (SEQ ID NO: 20), a LC CDR2 sequence of EDSRRPS (SEQ ID NO: 56), and a LC CDR3 sequence of QAWDSSTAI (SEQ ID NO: 92);
(vii) a VH sequence comprising a HC CDR1 sequence of HYRMS (SEQ ID NO: 129), a HC CDR2 sequence of SIYPSGGRTVYADSVKG (SEQ ID NO: 165), a HC CDR3 sequence of DKFEWRLLFRGIGNDAFDI (SEQ ID NO: 201), a LC CDR1 sequence of SGDKLGDKYTS (SEQ ID NO: 21), a LC CDR2 sequence of QDIKRPS (SEQ ID NO: 57), and a LC CDR3 sequence of QAWDSPNARV (SEQ ID NO: 93);
(viii) a VH sequence comprising a HC CDR1 sequence of RYIMH (SEQ ID NO: 137), a HC CDR2 sequence of SISPSGGLTSYADSVKG (SEQ ID NO: 173), a HC CDR3 sequence of EFENAYHYYYYGMDV (SEQ ID NO: 209), a LC CDR1 sequence of RASGDIGNALG (SEQ ID NO: 29), a LC CDR2 sequence of DASTLQS (SEQ ID NO: 65), and a LC CDR3 sequence of LQGYNYPRT (SEQ ID NO: 101);
(ix) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1111), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1112), a HC CDR3 sequence of VARGIAARSRTSYFDY (SEQ ID NO: 1113), a LC CDR1 sequence of RAGRSISTYVN (SEQ ID NO: 1093), a LC CDR2 sequence of AASSLQS (SEQ ID NO 1099), and a LC CDR3 sequence of QQSQSTPYT (SEQ ID NO: 1105);
(x) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1111), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1112), a HC CDR3 sequence of VARGIAARSRTSYFDY (SEQ ID NO: 1113), a LC CDR1 sequence of RASQIVSSRYLA (SEQ ID NO: 1094), a LC CDR2 sequence of GAASRAT (SEQ ID NO: 1100), and a LC CDR3 sequence of QQTYSSPFT (SEQ ID NO: 1106);
(xi) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1111), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1112), a HC CDR3 sequence of VARGIAARSRTSYFDY (SEQ ID NO: 1113), a LC CDR1 sequence of RASQSISNYLN (SEQ ID NO: 1095), a LC CDR2 sequence of AASSLQS (SEQ ID NO: 1101), and a LC CDR3 sequence of QQSYTSPYT (SEQ ID NO: 1107);
(xii) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1111), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1112), a HC CDR3 sequence of VARGIAARSRTSYFDY (SEQ ID NO: 1113), a LC CDR1 sequence of RASQIVSSNYLA (SEQ ID NO: 1096), a LC CDR2 sequence of GASNRAT (SEQ ID NO: 1102), and a LC CDR3 sequence of QQSFNIPYT (SEQ ID NO: 1108);
(xiii) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1111), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1112), a HC CDR3 sequence of VARGIAARSRTSYFDY (SEQ ID NO: 1113), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1097), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1103), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1109);
(xiv) a VH sequence comprising a HC CDR1 sequence of HYIMM (SEQ ID NO: 1127), a HC CDR2 sequence of GIYSSGGITVYADSVKG (SEQ ID NO: 1209), a HC CDR3 sequence of QRTGVPRRDSFNI (SEQ ID NO: 1291), a LC CDR1 sequence of RASQSISSWLA (SEQ ID NO: 1124), a LC CDR2 sequence of KASTLES (SEQ ID NO: 1125), and a LC CDR3 sequence of QQYNTYWT (SEQ ID NO: 1126);
(xv) a VH sequence comprising a HC CDR1 sequence of IYSMH (SEQ ID NO: 1128), a HC CDR2 sequence of SIYPSRGMTWYADSVKG (SEQ ID NO: 1210), a HC CDR3 sequence of RRTGIPRRDAFDI (SEQ ID NO: 1292), a LC CDR1 sequence of RASQSISSWLA (SEQ ID NO: 1124), a LC CDR2 sequence of KASTLES (SEQ ID NO: 1125), and a LC CDR3 sequence of QQYNTYWT (SEQ ID NO: 1126);
(xvi) a VH sequence comprising a HC CDR1 sequence of VYNMH (SEQ ID NO: 1129), a HC CDR2 sequence of SIYPSGGMTYYADSVKG (SEQ ID NO: 1211), a HC CDR3 sequence of RRTGIPRRDAFDI (SEQ ID NO: 1293), a LC CDR1 sequence of RASQSISSWLA (SEQ ID NO: 1124), a LC CDR2 sequence of KASTLES (SEQ ID NO: 1125), and a LC CDR3 sequence of QQYNTYWT (SEQ ID NO: 1126);
(xvii) a VH sequence comprising a HC CDR1 sequence of HYIMM (SEQ ID NO: 1130), a HC CDR2 sequence of GIYSSGGITVYADSVKG (SEQ ID NO: 1212), a HC CDR3 sequence of RRIGVPRRDEFDI (SEQ ID NO: 1294), a LC CDR1 sequence of RASQSISSWLA (SEQ ID NO: 1124), a LC CDR2 sequence of KASTLES (SEQ ID NO: 1125), and a LC CDR3 sequence of QQYNTYWT (SEQ ID NO: 1126);
(xviii) a VH sequence comprising a HC CDR1 sequence of HYIMM (SEQ ID NO: 1131), a HC CDR2 sequence of GIYSSGGITVYADSVKG (SEQ ID NO: 1213), a HC CDR3 sequence of RRTGVPRWDDFDI (SEQ ID NO: 1295), a LC CDR1 sequence of RASQSISSWLA (SEQ ID NO: 1124), a LC CDR2 sequence of KASTLES (SEQ ID NO: 1125), and a LC CDR3 sequence of QQYNTYWT (SEQ ID NO: 1126);
(xix) a VH sequence comprising a HC CDR1 sequence of IYSMH (SEQ ID NO: 1132), a HC CDR2 sequence of SIYSSGGPTKYADSVKG (SEQ ID NO: 1214), a HC CDR3 sequence of RRTGIPRRDAFDI (SEQ ID NO: 1296), a LC CDR1 sequence of RASQSISSWLA (SEQ ID NO: 1124), a LC CDR2 sequence of KASTLES (SEQ ID NO: 1125), and a LC CDR3 sequence of QQYNTYWT (SEQ ID NO: 1126);
(xx) a VH sequence comprising a HC CDR1 sequence of HYIMM (SEQ ID NO: 1133), a HC CDR2 sequence of GIYSSGGITVYADSVKG (SEQ ID NO: 1215), a HC CDR3 sequence of RRIGVPRRDSFDM (SEQ ID NO: 1297), a LC CDR1 sequence of RASQSISSWLA (SEQ ID NO: 1124), a LC CDR2 sequence of KASTLES (SEQ ID NO: 1125), and a LC CDR3 sequence of QQYNTYWT (SEQ ID NO: 1126);
(xxi) a VH sequence comprising a HC CDR1 sequence of HYIMM (SEQ ID NO: 1135), a HC CDR2 sequence of GIYSSGGITVYADSVKG (SEQ ID NO: 1217), a HC CDR3 sequence of RRTGVPRRDEFDI (SEQ ID NO: 1299), a LC CDR1 sequence of RASQSISSWLA (SEQ ID NO: 1124), a LC CDR2 sequence of KASTLES (SEQ ID NO: 1125), and a LC CDR3 sequence of QQYNTYWT (SEQ ID NO: 1126);
(xxii) a VH sequence comprising a HC CDR1 sequence of HYIMM (SEQ ID NO: 1137), a HC CDR2 sequence of GIYSSGGITVYADSVKG (SEQ ID NO: 1219), a HC CDR3 sequence of RRIGVPRRDSFDI (SEQ ID NO: 1301), a LC CDR1 sequence of RASQSISSWLA (SEQ ID NO: 1124), a LC CDR2 sequence of KASTLES (SEQ ID NO: 1125), and a LC CDR3 sequence of QQYNTYWT (SEQ ID NO: 1126);
(xxiii) a VH sequence comprising a HC CDR1 sequence of VYNMH (SEQ ID NO: 1138), a HC CDR2 sequence of SIYPSGGMTTYADSVKG (SEQ ID NO: 1220), a HC CDR3 sequence of RRTGIPRRDAFDI (SEQ ID NO: 1302), a LC CDR1 sequence of RASQSISSWLA (SEQ ID NO: 1124), a LC CDR2 sequence of KASTLES (SEQ ID NO: 1125), and a LC CDR3 sequence of QQYNTYWT (SEQ ID NO: 1126);
(xxiv) a VH sequence comprising a HC CDR1 sequence of HYIMM (SEQ ID NO: 1140), a HC CDR2 sequence of GIYSSGGITVYADSVKG (SEQ ID NO: 1222), a HC CDR3 sequence of RRTGVPRRDSFDI (SEQ ID NO: 1304), a LC CDR1 sequence of RASQSISSWLA (SEQ ID NO: 1124), a LC CDR2 sequence of KASTLES (SEQ ID NO: 1125), and a LC CDR3 sequence of QQYNTYWT (SEQ ID NO: 1126);
(xxv) a VH sequence comprising a HC CDR1 sequence of RYSMR (SEQ ID NO: 1142), a HC CDR2 sequence of VIYPSGGQTYYADSVKG (SEQ ID NO: 1224), a HC CDR3 sequence of RRTGIPRRDAFDI (SEQ ID NO: 1306), a LC CDR1 sequence of RASQSISSWLA (SEQ ID NO: 1124), a LC CDR2 sequence of KASTLES (SEQ ID NO: 1125), and a LC CDR3 sequence of QQYNTYWT (SEQ ID NO: 1126);
(xxvi) a VH sequence comprising a HC CDR1 sequence of HYIMM (SEQ ID NO: 1146), a HC CDR2 sequence of GIYSSGGITVYADSVKG (SEQ ID NO: 1228), a HC CDR3 sequence of RRTGVPRRDDFDI (SEQ ID NO: 1310), a LC CDR1 sequence of RASQSISSWLA (SEQ ID NO: 1124), a LC CDR2 sequence of KASTLES (SEQ ID NO: 1125), and a LC CDR3 sequence of QQYNTYWT (SEQ ID NO: 1126);
(xxvii) a VH sequence comprising a HC CDR1 sequence of HYIMM (SEQ ID NO: 1153), a HC CDR2 sequence of GIYSSGGITVYADSVKG (SEQ ID NO: 1235), a HC CDR3 sequence of RRIGVPRRDDFDI (SEQ ID NO: 1317), a LC CDR1 sequence of RASQSISSWLA (SEQ ID NO: 1124), a LC CDR2 sequence of KASTLES (SEQ ID NO: 1125), and a LC CDR3 sequence of QQYNTYWT (SEQ ID NO: 1126);
(xxviii) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1540), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1602), a HC CDR3 sequence of VARGIAARSRTSYLDQ (SEQ ID NO: 1664), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxix) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1541), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1603), a HC CDR3 sequence of VGQGIRGRSRTSYFAQ (SEQ ID NO: 1665), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxx) a VH sequence comprising a HC CDR1 sequence of DYMMA (SEQ ID NO: 1542), a HC CDR2 sequence of SIVPSGGHTHYADSVKG (SEQ ID NO: 1604), a HC CDR3 sequence of VARGIAARSRTSYFDY (SEQ ID NO: 1666), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxi) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1543), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1605), a HC CDR3 sequence of VAQGIAARSRTSSVDQ (SEQ ID NO: 1667), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxii) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1544), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1606), a HC CDR3 sequence of VARGIAARSRTSFFDY (SEQ ID NO: 1668), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxiii) a VH sequence comprising a HC CDR1 sequence of QYLMA (SEQ ID NO: 1545), a HC CDR2 sequence of SIYPSGGWTKYADSVKG (SEQ ID NO: 1607), a HC CDR3 sequence of VARGIAARSRTSYFDY (SEQ ID NO: 1669), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxiv) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1546), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1608), a HC CDR3 sequence of VARGIASRSRTRYCDY (SEQ ID NO: 1670), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxv) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1547), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1609), a HC CDR3 sequence of VATGIVARSRTRYFDQ (SEQ ID NO: 1671), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxvi) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1548), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1610), a HC CDR3 sequence of VARGIAARSRTRYFDY (SEQ ID NO: 1672), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxvii) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1549), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1611), a HC CDR3 sequence of VAQGISARSRTSYFDY (SEQ ID NO: 1673), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxviii) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1550), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1612), a HC CDR3 sequence of VAQGIVARSRTSYLHQ (SEQ ID NO: 1674), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxix) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1552), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1614), a HC CDR3 sequence of VARGIAARSRTSYLDY (SEQ ID NO: 1676), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxx) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1554), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1616), a HC CDR3 sequence of VARGIAARSRTRYFDQ (SEQ ID NO: 1678), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxxi) a VH sequence comprising a HC CDR1 sequence of GYMMV (SEQ ID NO: 1555), a HC CDR2 sequence of RISPSGGPTIYADSVKG (SEQ ID NO: 1617), a HC CDR3 sequence of VARGIAARSRTSYFDY (SEQ ID NO: 1679), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxxii) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1556), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1618), a HC CDR3 sequence of VARGIAARSRTSYFDQ (SEQ ID NO: 1680), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxxiii) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1557), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1619), a HC CDR3 sequence of VARGIAARSRTILLDQ (SEQ ID NO: 1681), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxxiv) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1558), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1620), a HC CDR3 sequence of VARGIAARSRTSFIDY (SEQ ID NO: 1682), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxxv) a VH sequence comprising a HC CDR1 sequence of TYKMQ (SEQ ID NO: 1559), a HC CDR2 sequence of SISPSGGPTNYADSVKG (SEQ ID NO: 1621), a HC CDR3 sequence of VARGIAARSRTSYFDY (SEQ ID NO: 1683), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539);
(xxxxvi) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1560), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1622), a HC CDR3 sequence of VARGIAARSRTSYLDF (SEQ ID NO: 1684), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539); or
(xxxxvii) a VH sequence comprising a HC CDR1 sequence of HYLMT (SEQ ID NO: 1562), a HC CDR2 sequence of YISPSGGHTIYADSVKG (SEQ ID NO: 1624), a HC CDR3 sequence of VARGIAARSRTSYFNQ (SEQ ID NO: 1686), a LC CDR1 sequence of RTSQFVNSNYLA (SEQ ID NO: 1537), a LC CDR2 sequence of GASSRAT (SEQ ID NO: 1538), and a LC CDR3 sequence of QQSSRTPWT (SEQ ID NO: 1539).
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