US 12,460,009 B2
Monoclonal antibodies specific for IL20-Rb, encoding nucleic acids thereof and methods of use thereof to treat bacterial-induced exacerbation of chronic obstructive pulmonary disease
Philippe Gosset, Lille (FR); Muriel Pichavant, Lille (FR); Pierre Martineau, Montpellier (FR); Myriam Chentouf, Montpellier (FR); Bruno Robert, Montpellier (FR); and Mélina Le Roux, Tourcoing (FR)
Assigned to INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Paris (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris (FR); UNIVERSITE DE LILLE, Paris (FR); INSTITUT PASTEUR DE LILLE, Lille (FR); UNIVERSITE DE MONTPELLIER, Montpellier (FR); and INSTITUT REGIONAL DU CANCER DE MONTPELLIER, Montpellier (FR)
Appl. No. 17/638,464
Filed by INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), Paris (FR); Centre National de la Recherche Scientifique (CNRS), Paris (FR); Université de Lille, Lille (FR); Institut Pasteur de Lille, Lille (FR); Université de Montpellier, Montpellier (FR); and INSTITUT RÉGIONAL DU CANCER DE MONTPELLIER, Montpellier (FR)
PCT Filed Sep. 3, 2020, PCT No. PCT/EP2020/074660
§ 371(c)(1), (2) Date Feb. 25, 2022,
PCT Pub. No. WO2021/043933, PCT Pub. Date Mar. 11, 2021.
Claims priority of application No. 19306068 (EP), filed on Sep. 4, 2019.
Prior Publication US 2023/0002497 A1, Jan. 5, 2023
Int. Cl. C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61P 11/00 (2006.01)
CPC C07K 16/2866 (2013.01) [A61P 11/00 (2018.01); A61K 39/00 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01)] 19 Claims
 
1. A monoclonal antibody which cross-competes for binding to IL-20Rb with the monoclonal antibody comprising a heavy chain comprising the following CDRs i) the VH-CDR1 as set forth in SEQ ID NO:2 (NY-X3-MN wherein X3 is S or A), ii) the VH-CDR2 as set forth in SEQ ID NO:3 (YISGSSRYISYADFVKG) and iii) the VH-CDR3 as set forth in SEQ ID NO:4 (SYYGMDV) and a light chain comprising the following CDRs: i) the VL-CDR1 as set forth in SEQ ID NO:5 (AGTSSDVGGNYYVS), ii) the VL-CDR2 as set forth in SEQ ID NO:6 (GDSYRPS) and iii) the VL-CDR3 as set forth in SEQ ID NO:7 (SSYTYYSTRV).