Synthesis of trans-8-chloro-5-methyl-1 -[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[e]azulene and crystalline forms thereof
Benno Rothenhaeusler, Loerrach (DE); Rene Trussardi, Birsfelden (CH); Fabienne Hoffmann-Emery, Weil am Rhein (DE); Urs Schwitter, Reinach (CH); Jean-Michel Adam, Village-Neuf (FR); Olaf Grassmann, Loerrach (DE); Thomas Hartung, Loerrach (DE); Frederic Ran, Kembs (FR); Ralph Diodone, Breisach (DE); Christophe Pfleger, Mulhouse (FR); and Bjorn Bartels, Schopfheim (DE)
Assigned to Hoffmann-La Roche Inc., Little Falls, NJ (US)
Filed by Hoffmann-La Roche Inc., Little Falls, NJ (US)
Filed on Jun. 3, 2021, as Appl. No. 17/337,547.
Application 17/337,547 is a division of application No. 16/291,887, filed on Mar. 4, 2019, granted, now 11,040,977.
Application 16/291,887 is a division of application No. 15/172,542, filed on Jun. 3, 2016, granted, now 10,246,460.
Application 15/172,542 is a continuation of application No. PCT/EP2014/076041, filed on Dec. 1, 2014.
Claims priority of application No. 13195864 (EP), filed on Dec. 5, 2013.
Prior Publication US 2021/0284648 A1, Sep. 16, 2021
