US 12,459,930 B2
Compounds for the inhibition of unregulated cell growth
Sandip Gavade, Maharashtra (IN); Maithili Athavale, Maharashtra (IN); Sangeeta Srivastava, Maharashtra (IN); and Prashant Kharkar, Maharashtra (IN)
Assigned to GODAVARI BIOREFINERIES LIMITED, Maharashtra (IN)
Appl. No. 17/415,676
Filed by GODAVARI BIOREFINERIES LIMITED, Maharashtra (IN)
PCT Filed Dec. 16, 2019, PCT No. PCT/IN2019/050926
§ 371(c)(1), (2) Date Jun. 17, 2021,
PCT Pub. No. WO2020/129082, PCT Pub. Date Jun. 25, 2020.
Claims priority of application No. 201821047582 (IN), filed on Dec. 17, 2018.
Prior Publication US 2022/0073501 A1, Mar. 10, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 407/04 (2006.01); A61P 35/00 (2006.01); C07D 295/088 (2006.01); C07D 317/54 (2006.01); C07D 405/04 (2006.01); C07D 493/04 (2006.01)
CPC C07D 407/04 (2013.01) [A61P 35/00 (2018.01); C07D 295/088 (2013.01); C07D 317/54 (2013.01); C07D 405/04 (2013.01); C07D 493/04 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A compound of Formula I:

OG Complex Work Unit Chemistry
wherein,
E and Z is selected from C and N;
Q is O;
R5 is —H or —Cl;
R6 and R7 each independently is selected from —H, or R6 and R7 together form a heterocyclic ring;
R8 is —H;
R10 is selected from

OG Complex Work Unit Chemistry
 R′ is selected from —H and alkoxy;
R11 and R12 each independently is selected from —H, or R11 and R12 can be substituted or unsubstituted lactone;
R is selected from

OG Complex Work Unit Chemistry
 or salts thereof;
and
n is selected from 2, 4 and 6.