US 12,459,919 B2
Polymorphic forms of (R)-4-(1-((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)sulfonyl)-1- fluoroethyl)-N-(isoxazol-3-yl)piperidine-1-carboxamide
Min Zhong, Palo Alto, CA (US); Olivier Monnier, Villeveyrac (FR); Jean-Philippe Jelin, Montpellier (FR); Richard Duvoux, Montpellier (FR); Jean Alie, Montpellier (FR); and Philippe Ochsenbein, Montpellier (FR)
Assigned to MYOKARDIA, INC., Brisbane, CA (US)
Filed by MyoKardia, Inc., Brisbane, CA (US)
Filed on Feb. 23, 2022, as Appl. No. 17/678,569.
Application 17/678,569 is a continuation of application No. 16/929,230, filed on Jul. 15, 2020, abandoned.
Claims priority of provisional application 62/874,855, filed on Jul. 16, 2019.
Prior Publication US 2022/0289709 A1, Sep. 15, 2022
Int. Cl. C07D 401/12 (2006.01); A61K 9/00 (2006.01)
CPC C07D 401/12 (2013.01) [A61K 9/0019 (2013.01); C07B 2200/13 (2013.01)] 38 Claims
 
1. A polymorph of compound formula (I-491):

OG Complex Work Unit Chemistry
wherein the polymorph is Form B of compound (I-491), characterized by an endotherm at about 170° C. to about 185° C.