US 12,459,917 B2
Salt of diaminopyrimidine compounds, and solid form thereof, preparation method therefor and use thereof
Yanping Zhao, Beijing (CN); Hongjun Wang, Beijing (CN); Zewang Feng, Beijing (CN); Huai Huang, Beijing (CN); Kai Liu, Beijing (CN); Xuelian Liu, Beijing (CN); Jianmei Pang, Beijing (CN); Nana Tian, Beijing (CN); Xichao Chen, Beijing (CN); Shenzhen Fu, Beijing (CN); Jie Meng, Beijing (CN); Liying Zhou, Beijing (CN); and Yanan Liu, Beijing (CN)
Assigned to BEIJING TIDE PHARMACEUTICAL CO., LTD., Beijing (CN)
Appl. No. 17/607,464
Filed by BEIJING TIDE PHARMACEUTICAL CO., LTD., Beijing (CN)
PCT Filed Apr. 29, 2020, PCT No. PCT/CN2020/087688
§ 371(c)(1), (2) Date Oct. 29, 2021,
PCT Pub. No. WO2020/221276, PCT Pub. Date Nov. 5, 2020.
Claims priority of application No. PCT/CN2019/085208 (WO), filed on Apr. 30, 2019.
Prior Publication US 2022/0177447 A1, Jun. 9, 2022
Int. Cl. C07D 401/12 (2006.01)
CPC C07D 401/12 (2013.01) [C07B 2200/13 (2013.01)] 16 Claims
 
1. A salt of Compound A,

OG Complex Work Unit Chemistry
which is Compound A hydrochloride;
the molar ratio of Compound A to hydrochloric acid is 1:1;
the Compound A hydrochloride is in crystalline form Ia;
the crystalline form Ia has an XRPD pattern comprising characteristic peaks at diffraction angles (20) of 7.8±0.2°, 10.4±0.2°, 15.7±0.2°, 20.0±0.2°, 20.7±0.2°, 22.3±0.2° and 26.0±0.2°.