US 12,459,913 B2
Preparation of substituted pyrazoles and their use as anthranilamides precursors
Thomas Zell, Beer Sheva (IL); Jie Li, Nanjing (CN); Itsik Bar-Nahum, Kfar-Gibton (IL); and Avihai Yacovan, Mazkeret Batya (IL)
Assigned to ADAMA MAKHTESHIM LTD., Beer Sheva (IL)
Appl. No. 17/604,935
Filed by ADAMA MAKHTESHIM LTD., Beer-Sheva (IL)
PCT Filed Apr. 16, 2020, PCT No. PCT/IL2020/050450
§ 371(c)(1), (2) Date Oct. 19, 2021,
PCT Pub. No. WO2020/212991, PCT Pub. Date Oct. 22, 2020.
Claims priority of application No. 201910317694.4 (CN), filed on Apr. 19, 2019.
Prior Publication US 2022/0177444 A1, Jun. 9, 2022
Int. Cl. C07D 401/04 (2006.01); C07D 231/14 (2006.01); C07D 231/16 (2006.01)
CPC C07D 401/04 (2013.01) [C07D 231/14 (2013.01); C07D 231/16 (2013.01)] 6 Claims
 
1. A method of preparing a compound of Formula I:

OG Complex Work Unit Chemistry
by reacting of a compound of Formula II

OG Complex Work Unit Chemistry
with pyridine of Formula III:

OG Complex Work Unit Chemistry
wherein L is a leaving group, selected from halogen and halogenated or not halogenated sulfonyl group, in the presence of base and organic solvent, optionally in the presence of a catalyst.