US 12,459,900 B2
Compounds for treating conditions related to oxidative stress
Rajan Shobhanath Giri, Naperville, IL (US)
Appl. No. 17/802,239
Filed by Rajan Shobhanath Giri, Naperville, IL (US)
PCT Filed Mar. 10, 2022, PCT No. PCT/US2022/019657
§ 371(c)(1), (2) Date Aug. 25, 2022,
PCT Pub. No. WO2022/192477, PCT Pub. Date Sep. 15, 2022.
Claims priority of provisional application 63/159,081, filed on Mar. 10, 2021.
Prior Publication US 2024/0262794 A1, Aug. 8, 2024
Int. Cl. C07D 231/08 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 31/4152 (2006.01); A61K 31/675 (2006.01); A61P 27/02 (2006.01); C07D 405/12 (2006.01); C07F 9/6503 (2006.01)
CPC C07D 231/08 (2013.01) [A61K 9/0048 (2013.01); A61K 9/08 (2013.01); A61K 31/4152 (2013.01); A61K 31/675 (2013.01); A61P 27/02 (2018.01); C07D 405/12 (2013.01); C07F 9/65031 (2013.01)] 15 Claims
 
1. A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, optical isomer, or combination thereof,

OG Complex Work Unit Chemistry
wherein:
custom character represents single or double bond
R1 and R2 is selected form the group consisting of —H, —C1-20 alkyl, C2-20-alkenyl, and C2-20-alkynyl, optionally mono-, di- or tri-substituted with halogen, substituted and unsubstituted Aryl, substituted and unsubstituted heteroaryl (mono and bicyclic)
R3 is selected from the group consisting of —H, —C1-20 alkyl, C2-20-alkenyl, and C2-20-alkynyl, wherein R3 may be substituted by one or more A; aryl and heteroaryl
R4 is selected from the group consisting of —H, —C1-20 alkyl, C2-20-alkenyl, and C2-20 alkynyl, wherein R4 may be substituted by one or more A;
R5 is selected from the group consisting of (a) aryl, (b) heteroaryl, (c) —C1-2 alkyl-aryl, and (d) —C1-2 alkyl-heteroaryl,
wherein A is aryl or heteroaryl;
wherein the aryl of choices (a) and (c), and the heteroaryl of choices (b) and (d), are optionally mono-, di- or tri-substituted with substituents selected from the group consisting of halogen, —C1-6 alkyl, —CF3, —OCF3, —C1-6 alkoxy, —C3-6 cycloalkoxy, halo-C1-6 alkyl, aryl, heteroaryl, heterocyclo, —C3-6 cycloalkyl, and —C3-6 cycloalkenyl;
provided at least one out of the R1, R2, R3, R4 and R5 is selected from the group consisting of

OG Complex Work Unit Chemistry
wherein X, Y, Z are selected from the group consisting of —H, methyl, ethyl, propyl, butyl, substituted or unsubstituted aryl and heteroaryls; n is an integer selected from 0-18 and E is phosphorous or nitrogen atom.