US 12,459,896 B2
Process for preparing 4-methyl-2-propan-2-yl-pyridine-3-carbonitrile
Austin Gerald Smith, Cary, NC (US); Padmini Kavuru Ananthoji, Townsend, MA (US); Peter Dornan, Stoneham, MA (US); and Xijie Dai, Winchester, MA (US)
Assigned to AMGEN INC., Thousand Oaks, CA (US)
Filed by AMGEN INC., Thousand Oaks, CA (US)
Filed on Dec. 19, 2024, as Appl. No. 18/988,131.
Application 18/988,131 is a continuation of application No. 18/842,194, previously published as PCT/US2023/063755, filed on Mar. 6, 2023.
Claims priority of provisional application 63/317,187, filed on Mar. 7, 2022.
Prior Publication US 2025/0206705 A1, Jun. 26, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 471/04 (2006.01); C07D 207/06 (2006.01); C07D 213/73 (2006.01); C07D 213/82 (2006.01); C07D 213/85 (2006.01)
CPC C07D 213/85 (2013.01) [C07D 207/06 (2013.01); C07D 213/73 (2013.01); C07D 213/82 (2013.01); C07D 471/04 (2013.01)] 22 Claims
 
1. A process for preparing Compound A or a salt thereof

OG Complex Work Unit Chemistry
comprising:
admixing Compound B

OG Complex Work Unit Chemistry
 or a salt thereof, and crotonaldehyde in a solvent and in the presence of a catalytic reagent;
wherein the catalytic reagent comprises an acid catalyst, an organocatalyst, or a combination thereof.