US 12,459,886 B2
Branched-chain amino acid crystallization method capable of sustainably cycling ammonia
Jun Woo Kim, Seoul (KR); Shin Ae Park, Seoul (KR); Ji Hyun Shin, Seoul (KR); Jae Hun Yu, Seoul (KR); Chang Yub Oh, Seoul (KR); and Min Jong Kim, Seoul (KR)
Assigned to CJ CHEILJEDANG CORPORATION, Seoul (KR)
Appl. No. 17/768,272
Filed by CJ CHEILJEDANG CORPORATION, Seoul (KR)
PCT Filed Nov. 9, 2020, PCT No. PCT/KR2020/015633
§ 371(c)(1), (2) Date Apr. 12, 2022,
PCT Pub. No. WO2021/107451, PCT Pub. Date Jun. 3, 2021.
Claims priority of application No. 10-2019-0152229 (KR), filed on Nov. 25, 2019.
Prior Publication US 2024/0132442 A1, Apr. 25, 2024
Prior Publication US 2024/0228430 A9, Jul. 11, 2024
Int. Cl. C07C 229/08 (2006.01)
CPC C07C 229/08 (2013.01) [C07B 2200/13 (2013.01)] 10 Claims
 
1. A crystallization method of branched-chain amino acids comprising:
(a) mixing a reaction solution containing branched-chain amino acid crystals with ammonia to obtain a solution in which the branched-chain amino acid crystals are dissolved;
(b) crystallizing the obtained solution to obtain a concentrate containing branched-chain amino acid crystals;
(c) obtaining a mixed gas including water vapor and ammonia, generated in the crystallization process; and
(d) reusing ammonia derived from the obtained mixed gas as ammonia of the process (a); wherein the process (b) and process (c) are carried out simultaneously or sequentially,
wherein in the process (a), a pH of the solution in which the branched-chain amino acid crystals are dissolved is 9 to 12.