US 12,459,876 B2
One-step kit-based synthesis of 2-deoxy-2-[18F]fluoro-D-sorbitol
Sanjay K. Jain, Baltimore, MD (US); Filipa Mota, Baltimore, MD (US); and Alvaro A. Ordonez, Baltimore, MD (US)
Assigned to The Johns Hopkins University, Baltimore, MD (US)
Appl. No. 18/043,538
Filed by The Johns Hopkins University, Baltimore, MD (US)
PCT Filed Aug. 27, 2021, PCT No. PCT/US2021/048019
§ 371(c)(1), (2) Date Feb. 28, 2023,
PCT Pub. No. WO2022/047202, PCT Pub. Date Mar. 3, 2022.
Claims priority of provisional application 63/071,755, filed on Aug. 28, 2020.
Prior Publication US 2023/0265024 A1, Aug. 24, 2023
Int. Cl. C07B 59/00 (2006.01)
CPC C07B 59/005 (2013.01) [C07B 2200/05 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A method for preparing 2-deoxy-2-[18F]fluoro-D-sorbitol (18F-FDS), the method comprising:
(a) providing an aliquot of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG);
(b) contacting the aliquot of 18F-FDG with a solid-supported borohydride source to form 18F-FDS; and
(c) purifying the 18F-FDS by contacting the 18F-FDS formed in step (b) with a cation exchange resin comprising PS—H+ or an anion exchange resin comprising PSHCO3.