US 12,458,815 B2
Dose volume histogram optimization based on quantile regression
Jens Olof Sjolund, Uppsala (SE); and Carl Axel Håkan Nordström, Sollentuna (SE)
Assigned to Elekta Instrument AB, Stockholm (SE)
Filed by Elekta Instrument AB, Stockholm (SE)
Filed on Feb. 18, 2022, as Appl. No. 17/651,679.
Prior Publication US 2023/0264045 A1, Aug. 24, 2023
Int. Cl. A61N 5/10 (2006.01); G06F 17/18 (2006.01)
CPC A61N 5/1031 (2013.01) [G06F 17/18 (2013.01)] 26 Claims
OG exemplary drawing
 
1. A computer-implemented method for generating a radiotherapy treatment plan for a patient, the method comprising:
receiving, by processor circuitry, a plurality of treatment planning criteria including at least one dose-volume criterion that corresponds to a quantile of a dose-volume histogram;
determining a first radiotherapy optimization problem based on the received plurality of treatment planning criteria;
determining, for each quantile, a second radiotherapy optimization problem such that a solution to the second radiotherapy optimization problem estimates a radiotherapy dose that corresponds to a specified fractional portion of a volume of the patient, wherein the first radiotherapy optimization problem is processed based on solutions to at least one of the second radiotherapy optimization problems;
processing the first radiotherapy optimization problem and the second radiotherapy optimization problems corresponding to each quantile to determine mutually consistent solutions to both the first radiotherapy optimization problem and the second radiotherapy optimization problems corresponding to each quantile; and
processing the determined solutions to the first radiotherapy optimization problem to generate the radiotherapy treatment plan, wherein the radiotherapy treatment plan is used for delivering radiotherapy treatment to the patient for treatment of a tumor.