US 12,458,809 B2
Method and system of using plasma discharge tube for sensitization of cancer cells
Michael Keidar, Baltimore, MD (US); Dayun Yan, Ashburn, VA (US); Xiaoliang Yao, Fairfax, VA (US); Li Lin, Arlington, VA (US); Vikas Soni, Washington, DC (US); and Jonathan Sherman, Potomac, MD (US)
Assigned to THE GEORGE WASHINGTON UNIVERSITY, Washington, DC (US)
Appl. No. 17/620,032
Filed by The George Washington University, WasHington, DC (US)
PCT Filed Jul. 9, 2020, PCT No. PCT/US2020/041472
§ 371(c)(1), (2) Date Dec. 16, 2021,
PCT Pub. No. WO2021/007464, PCT Pub. Date Jan. 14, 2021.
Claims priority of provisional application 62/981,321, filed on Feb. 25, 2020.
Claims priority of provisional application 62/872,782, filed on Jul. 11, 2019.
Prior Publication US 2022/0305279 A1, Sep. 29, 2022
Int. Cl. A61N 2/00 (2006.01); A61K 31/495 (2006.01); A61N 5/10 (2006.01); A61P 35/00 (2006.01); A61B 18/00 (2006.01)
CPC A61N 2/004 (2013.01) [A61K 31/495 (2013.01); A61P 35/00 (2018.01); A61B 2018/00071 (2013.01); A61B 2018/00583 (2013.01); A61N 5/10 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for sensitization of cancerous cells in a volume including normal cells and the cancerous cells, comprising:
a power supply;
a plasma tube sealed on opposite ends including a pair of electrodes coupled to the power supply, the plasma tube generating a plasma jet between the electrodes; and
a controller coupled to the power supply to control a discharge voltage to the electrodes to generate the plasma jet and direct an electro-magnetic field at the volume having cancerous cells and normal cells for a sufficient time to sensitize the cancerous cells.