US 12,458,807 B2
Apparatus and methods for phase-agnostic stimuli
David Paydarfar, Austin, TX (US); Joshua Chang, Pflugerville, TX (US); Sara A. Santos, Austin, TX (US); and Varun K. Sridhar, Austin, TX (US)
Assigned to Research Development Foundation, Carson City, NV (US)
Filed by Research Development Foundation, Carson City, NV (US)
Filed on Oct. 20, 2021, as Appl. No. 17/506,019.
Claims priority of provisional application 63/114,636, filed on Nov. 17, 2020.
Claims priority of provisional application 63/104,998, filed on Oct. 23, 2020.
Prior Publication US 2022/0143412 A1, May 12, 2022
Int. Cl. A61N 1/00 (2006.01); A61N 1/05 (2006.01); A61N 1/36 (2006.01); A61N 1/378 (2006.01); G01R 25/00 (2006.01); G16H 20/00 (2018.01)
CPC A61N 1/378 (2013.01) [A61N 1/0534 (2013.01); A61N 1/36114 (2013.01); A61N 1/36125 (2013.01); A61N 1/36146 (2013.01); G01R 25/005 (2013.01); G16H 20/00 (2018.01)] 17 Claims
OG exemplary drawing
 
1. An apparatus for applying a therapeutic treatment to a subject, the apparatus comprising:
a stimulation electrode; and
a programmable arbitrary waveform generator, wherein the programmable arbitrary waveform generator is configured to:
receive a detected biological oscillator signal from the subject;
transmit a first stimulation signal to the subject via the stimulation electrode, wherein the first stimulation signal is transmitted at a phase of the detected biological oscillator signal;
receive a response signal from the subject; and
transmit a second stimulation signal to the subject via the stimulation electrode, wherein the second stimulation signal is configured to optimize the response signal without regard to the phase of the detected biological oscillator signal by suppressing oscillation in the detected biological oscillator signal while minimizing an electrical current level of the second stimulation, wherein:
the second stimulation signal is generated using an extrema distortion algorithm, a deep learning algorithm or a reinforcement learning algorithm.