US 12,458,800 B2
Devices and methods for treatment of tumors using electromagnetic signal
Clark C. Chen, Edina, MN (US); Gregory Frederick Molnar, Blaine, MN (US); and Sanjay Dhawan, Minneapolis, MN (US)
Assigned to Regents of the University of Minnesota, Minneapolis, MN (US)
Filed by Regents of the University of Minnesota, Minneapolis, MN (US)
Filed on Feb. 20, 2023, as Appl. No. 18/171,516.
Application 18/171,516 is a continuation of application No. 17/250,735, granted, now 11,623,085, previously published as PCT/US2019/048858, filed on Aug. 29, 2019.
Claims priority of provisional application 62/724,177, filed on Aug. 29, 2018.
Prior Publication US 2023/0201582 A1, Jun. 29, 2023
Int. Cl. A61N 1/05 (2006.01); A61N 1/36 (2006.01); A61N 1/372 (2006.01); A61N 1/40 (2006.01); B33Y 80/00 (2015.01)
CPC A61N 1/36002 (2017.08) [A61N 1/0534 (2013.01); A61N 1/36171 (2013.01); A61N 1/37211 (2013.01); A61N 1/40 (2013.01); B33Y 80/00 (2014.12)] 21 Claims
OG exemplary drawing
 
1. A signal generator comprising a processor, wherein the processor is configured to:
produce an output at a lead based upon a first set of electrical parameters corresponding to a first cell proliferation process, the lead configured to be implanted such that the generated electric field is applied by the lead from a location directly within a tumor, the first set of electrical parameters comprising one or more of an amplitude, a pulse width, a frequency, a waveform, a pulse shape, a pulse pattern, or a burst;
receive tumor image data;
detect a reduced effectiveness of the first set of electrical parameters, the reduced effectiveness corresponding to no detected change in a Volume of Tissue Activation (VTA) over time; and
in response to detecting a reduced effectiveness of the first set of electrical parameters, produce an output at the lead based upon a second set of electrical parameters corresponding to a second cell proliferation process.