| CPC A61M 5/16881 (2013.01) [A61M 5/172 (2013.01); A61M 5/168 (2013.01); A61M 5/16804 (2013.01); A61M 5/16827 (2013.01); A61M 5/16831 (2013.01); A61M 5/16836 (2013.01); A61M 5/1684 (2013.01); A61M 5/16877 (2013.01); A61M 5/16886 (2013.01); A61M 5/1723 (2013.01); A61M 60/50 (2021.01); A61M 2205/6009 (2013.01); A61M 2205/6018 (2013.01); A61M 2205/6054 (2013.01)] | 19 Claims |

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1. A system comprising:
a fluid port comprising:
a fluid channel;
a fluid inlet at a first end of the fluid channel configured to couple to an outlet of a manually administrable fluid source; and
a fluid outlet at a second end of the fluid channel configured to deliver fluid from the manually administrable fluid source to a fluid pathway that provides the fluid to a patient;
at least one sensor to characterize at least one attribute of the fluid from the manually administrable fluid source;
a flow controller in communication with the at least one sensor that generates at least one flow modification signal in response to the at least one attribute matching at least one condition specified by at least one rule; and
a flow control valve in communication with the flow controller and positioned along the fluid pathway at a location separate and distinct from the fluid port, the flow control valve changing a level of flow restriction of the fluid from the manually administrable fluid source passing therethrough in response to receiving the at least one flow modification signal,
wherein the at least one sensor comprises a fluid flow sensor,
wherein the flow controller is in communication with a rules engine, the rules engine using a plurality of rules including the at least one rule to determine whether the at least one attribute matches the at least one condition specified by the at least one rule,
wherein the plurality of rules is defined such that triggering an alert or a warning message to alert a clinician is an independent event from sending the at least one flow modification signal to the flow control valve, and
wherein the plurality of rules generate tiered messages and flow modification signals using multiple trigger thresholds based on a severity of a safety risk including generating the warning message to the clinician without sending the at least one flow medication signal to close the flow control valve when an administered dose reaches a first threshold greater than a physician ordered dose and generating an alert message and simultaneously sending the at least one flow modification signal to close the flow control valve when the administered dose reaches a second threshold greater than the first threshold.
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