US 12,458,728 B2
Tough tissue sealants and the use thereof
Amir Sheikhi, State College, PA (US); Maryam Tavafoghi, Los Angeles, CA (US); and Alireza Khademhosseini, Los Angeles, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Appl. No. 17/772,399
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Nov. 18, 2020, PCT No. PCT/US2020/061040
§ 371(c)(1), (2) Date Apr. 27, 2022,
PCT Pub. No. WO2021/101983, PCT Pub. Date May 27, 2021.
Claims priority of provisional application 62/936,808, filed on Nov. 18, 2019.
Prior Publication US 2022/0378975 A1, Dec. 1, 2022
Int. Cl. A61L 24/04 (2006.01); A61L 24/00 (2006.01); C08L 5/04 (2006.01); C08L 89/06 (2006.01)
CPC A61L 24/043 (2013.01) [A61L 24/0015 (2013.01); C08L 5/04 (2013.01); C08L 89/06 (2013.01); A61L 2400/04 (2013.01)] 20 Claims
 
1. A biocompatible composition of matter comprising:
from 1% to 4% (w/v) of a physically and chemically crosslinkable alginate;
from 10% to 30% (w/v) of a crosslinkable gelatin;
divalent ions; and
one or more visible light photoinitiators;
wherein the physically and chemically crosslinkable alginate and the crosslinkable gelatin are chemically crosslinked together; and
wherein the alginate has physical ionic crosslinks formed therein via the divalent ions.