US 12,458,727 B2
Anti-microbial medical materials and devices
Dana Wm. Ryan, Nolensville, TN (US); and Mitchell Corey Sanders, Grafton, MA (US)
Assigned to RYMED TECHNOLOGIES, LLC, Franklin, TN (US)
Filed by RyMed Technologies, LLC, Franklin, TN (US)
Filed on Aug. 19, 2021, as Appl. No. 17/406,934.
Application 17/406,934 is a continuation of application No. 15/473,435, filed on Mar. 29, 2017, abandoned.
Claims priority of provisional application 62/314,832, filed on Mar. 29, 2016.
Prior Publication US 2022/0354985 A1, Nov. 10, 2022
Int. Cl. A61L 15/22 (2006.01); A61L 15/42 (2006.01); A61L 27/54 (2006.01); A61L 27/56 (2006.01); A61L 29/04 (2006.01); A61L 29/08 (2006.01); A61L 29/14 (2006.01); A61L 29/16 (2006.01); A61L 31/14 (2006.01); A61L 31/16 (2006.01); A61M 25/00 (2006.01)
CPC A61L 15/225 (2013.01) [A61L 15/42 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 29/04 (2013.01); A61L 29/08 (2013.01); A61L 29/146 (2013.01); A61L 29/16 (2013.01); A61L 31/146 (2013.01); A61L 31/16 (2013.01); A61L 2300/106 (2013.01); A61L 2300/404 (2013.01); A61L 2400/08 (2013.01); A61L 2400/12 (2013.01); A61M 25/0045 (2013.01); A61M 2025/0056 (2013.01)] 10 Claims
 
1. A method of preparing an antimicrobial medical material having nanopores or nanochannels, and an antimicrobial agent disposed therein comprising:
providing a prepolymeric material;
polymerizing the prepolymeric material in the presence of a nanomaterial to form a medical polymer having the nanomaterial disposed therein;
removing the nanomaterial to provide a medical matrix having nanopores or nanochannels, wherein removing the nanomaterial comprises dissolving the nanomaterial with a dilute acid, the nanomaterial comprising calcium carbonate, liposomes, carbon nanotubes, nano-gold particles, silica nanoparticles or a combination thereof;
dissolving a first antimicrobial agent of the antimicrobial agent in a first antimicrobial solvent to provide a first antimicrobial solution;
dissolving a second antimicrobial agent of the antimicrobial agent in a second antimicrobial solvent to provide a second antimicrobial solution;
reacting a mixture of the first antimicrobial solution and the second antimicrobial solution to provide a co-nanocrystalline antimicrobial agent of the antimicrobial agent; and
loading into the nanopores or nanochannels of the medical matrix the co-nanocrystalline antimicrobial agent to provide the antimicrobial medical material.