	US 12,458,704 B2
	Multimeric elastin-like polypeptides
John Andrew Mackay, Los Angeles, CA (US); Mihir Shah, Los Angeles, CA (US); Sarah F. Hamm-Alvarez, Los Angeles, CA (US); Hao Guo, Los Angeles, CA (US); and Santosh Peddi, Los Angeles, CA (US)
Assigned to University of Southern California, Los Angeles, CA (US)
Filed by University of Southern California, Los Angeles, CA (US)
Filed on Oct. 10, 2022, as Appl. No. 17/963,037.
Application 17/963,037 is a continuation of application No. 16/274,192, filed on Feb. 12, 2019, granted, now 11,464,867.
Claims priority of provisional application 62/630,145, filed on Feb. 13, 2018.
Prior Publication US 2023/0181752 A1, Jun. 15, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/68 (2017.01); A61K 38/13 (2006.01); C12N 15/62 (2006.01); C07K 16/28 (2006.01)

CPC A61K 47/6801 (2017.08) [A61K 47/6849 (2017.08); A61K 38/13 (2013.01); C07K 16/2887 (2013.01); C12N 15/62 (2013.01)]

18 Claims

1. An agent comprising an elastin-like peptide (ELP) that comprises the amino acid sequence set forth in SEQ ID NO: 11 fused to an intracellular adhesion molecule 1 (ICAM-1) targeting peptide selected from an ICAM-1 targeting peptide that comprises EWCEYLGGYLRCYA (SEQ ID NO: 29) or FEGFSFLAFEDFVSSI (SEQ ID NO:28).