US 12,458,697 B2
Methods to rescue light sensitivity in retinas after photoreceptor degeneration
Joao Carvalho-de-Souza, Tucson, AZ (US); and Francisco Bezanilla, Chicago, IL (US)
Assigned to ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, Tucson, AZ (US); and THE UNIVERSITY OF CHICAGO, Chicago, IL (US)
Filed by ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, Tucson, AZ (US); and THE UNIVERSITY OF CHICAGO, Chicago, IL (US)
Filed on Jul. 5, 2022, as Appl. No. 17/857,818.
Claims priority of provisional application 63/218,092, filed on Jul. 2, 2021.
Prior Publication US 2023/0000985 A1, Jan. 5, 2023
Int. Cl. A61K 41/00 (2020.01); A61N 5/06 (2006.01)
CPC A61K 41/0057 (2013.01) [A61N 5/0622 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for treating vision loss caused by photoreceptor degeneration in a subject in need thereof, the method comprising:
a) introducing a light-to-heat transducer material comprising an anchoring molecule to an eye of the subject; and
b) pulsing a light source into the eye of the subject,
wherein the pulsing light is absorbed by the light-to-heat transducer material and stimulates a change in membrane capacitance to elicit a cell signal.