	US 12,458,664 B2
	Compositions and methods comprising energy absorbing materials for follicular delivery
Dilip Paithankar, Wayland, MA (US); Richard Dean Blomgren, Dacula, GA (US); Richard Rox Anderson, Boston, MA (US); William A. Farinelli, Danvers, MA (US); and Apostolos G. Doukas, Cambridge, MA (US)
Assigned to The General Hospital Corporation, Boston, MA (US)
Filed by The General Hospital Corporation, Boston, MA (US)
Filed on Jun. 30, 2023, as Appl. No. 18/345,919.
Application 18/345,919 is a continuation of application No. 16/876,835, filed on May 18, 2020, granted, now 11,730,758.
Application 16/876,835 is a continuation of application No. 16/596,309, filed on Oct. 8, 2019, abandoned.
Application 16/876,835 is a continuation of application No. 15/861,343, filed on Jan. 3, 2018, abandoned.
Application 16/596,309 is a continuation of application No. 15/459,184, filed on Mar. 15, 2017.
Application 15/861,343 is a continuation of application No. 14/951,444, filed on Nov. 24, 2015.
Application 15/459,184 is a continuation of application No. 13/828,429, filed on Mar. 14, 2013.
Application 14/951,444 is a continuation of application No. 13/789,575, filed on Mar. 7, 2013.
Claims priority of provisional application 61/636,381, filed on Apr. 20, 2012.
Prior Publication US 2024/0016835 A1, Jan. 18, 2024
Int. Cl. A61K 33/242 (2019.01); A61K 9/00 (2006.01); A61K 9/50 (2006.01); A61K 9/51 (2006.01); A61K 33/24 (2019.01); A61K 33/243 (2019.01); A61K 41/00 (2020.01)

CPC A61K 33/242 (2019.01) [A61K 9/0009 (2013.01); A61K 9/0014 (2013.01); A61K 9/50 (2013.01); A61K 9/5115 (2013.01); A61K 33/24 (2013.01); A61K 33/243 (2019.01); A61K 41/0047 (2013.01)]

6 Claims

1. A composition comprising a cosmetically acceptable carrier and a plurality of plasmonic nanoparticles in an amount effective to induce thermomodulation in a target tissue region with which the composition is topically contacted, the composition comprising:

a suspension of plasmonic particles, wherein the plasmonic particles comprise at least one of nanoplates, solid nanoshells, hollow nanoshells, nanorods, nanorice, nanospheres, nanofibers, nanowires, nanopyramids, nanoprisms, nanostars and a shell comprising at least one of silver, gold, nickel, copper, titanium, silicon, galadium, palladium, platinum, or chromium, wherein the plasmonic particles comprise a metal/dielectric interface, and wherein the suspension comprises:

20% to 73% alcohol;

1% to 9% polysorbate 80; and

12-65% water or plasmonic particles suspended in water,

wherein the plasmonic particles are not bound to each other through a physical force or chemical bond either directly or indirectly through an intermediary,

wherein a ratio of a shell diameter to a core diameter of the plasmonic particles is between above 1.5 to about 2.0.