	US 12,458,659 B2
	Methods for treating macrophage-mediated diseases, and methods of identifying agents useful therefore
Michael Karin, La Jolla, CA (US); and Elsa Sanchez-Lopez, La Jolla, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Appl. No. 17/428,544
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Feb. 4, 2020, PCT No. PCT/US2020/016637 § 371(c)(1), (2) Date Aug. 4, 2021, PCT Pub. No. WO2020/163374, PCT Pub. Date Aug. 13, 2020.
Claims priority of provisional application 62/801,973, filed on Feb. 6, 2019.
Prior Publication US 2022/0133770 A1, May 5, 2022
Int. Cl. A61K 31/713 (2006.01); A61K 45/06 (2006.01); C12N 15/113 (2010.01)

CPC A61K 31/713 (2013.01) [A61K 45/06 (2013.01); C12N 15/113 (2013.01); C12N 2310/122 (2013.01)]

6 Claims

1. A method of inhibiting choline phosphorylation in a subject comprising administering to the subject an effective amount of an shRNA comprising a nucleic acid sequence selected from SEQ ID NO: 11, 12, or 13.