US 12,458,646 B2
Therapeutic or preventing agent for multiple sclerosis including indole compound
Yoshifumi Ueda, Takatsuki (JP); Takafumi Kurimoto, Takatsuki (JP); and Naofumi Uesato, Takatsuki (JP)
Assigned to Japan Tobacco Inc., Tokyo (JP)
Appl. No. 17/056,947
Filed by JAPAN TOBACCO INC., Tokyo (JP)
PCT Filed May 24, 2019, PCT No. PCT/JP2019/020667
§ 371(c)(1), (2) Date Apr. 23, 2021,
PCT Pub. No. WO2019/225740, PCT Pub. Date Nov. 28, 2019.
Claims priority of application No. 2018-100668 (JP), filed on May 25, 2018.
Prior Publication US 2021/0236503 A1, Aug. 5, 2021
Int. Cl. A61K 31/5377 (2006.01); A61P 25/28 (2006.01)
CPC A61K 31/5377 (2013.01) [A61P 25/28 (2018.01)] 6 Claims
 
1. A method for treating multiple sclerosis in a human subject in need thereof, comprising administering to the human subject a therapeutically effective amount of a compound represented by the following chemical structural formula:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein the human subject has had a prior treatment with FTY-720, and wherein the prior treatment with FTY-720 is clinically insufficient.