Mary Ann Johnson, Norristown, PA (US); Leonardo R. Allain, Lansdale, PA (US); W. Mark Eickhoff, Lansdale, PA (US); Craig B. Ikeda, Harleysville, PA (US); Chad D. Brown, Quakertown, PA (US); Francis J. Flanagan, North Wales, PA (US); Rebecca Nofsinger, Lansdale, PA (US); Melanie Marota, Mount Laurel, NJ (US); Lisa Lupton, South San Francisco, CA (US); Paresh B. Patel, Langhorne, PA (US); Hanmi Xi, Furlong, PA (US); and Wei Xu, West Point, PA (US)
Assigned to Merck Sharp & Dohme LLC, Rahway, NJ (US)
Filed by Merck Sharp & Dohme LLC, Rahway, NJ (US)
Filed on Jan. 31, 2025, as Appl. No. 19/042,453.
Application 18/663,025 is a division of application No. 18/440,217, filed on Feb. 13, 2024, abandoned.
Application 19/042,453 is a continuation of application No. 18/945,079, filed on Nov. 12, 2024.
Application 18/945,079 is a continuation of application No. 18/889,824, filed on Sep. 19, 2024, granted, now 12,310,953, issued on May 27, 2025.
Application 18/889,824 is a continuation of application No. 18/776,516, filed on Jul. 18, 2024, granted, now 12,220,408, issued on Feb. 11, 2025.
Application 18/776,516 is a continuation of application No. 18/663,025, filed on May 13, 2024, granted, now 12,168,004, issued on Dec. 17, 2024.
Application 18/440,217 is a continuation in part of application No. 18/523,481, filed on Nov. 29, 2023, granted, now 12,070,450, issued on Aug. 27, 2024.
Application 18/523,481 is a continuation of application No. 18/210,719, filed on Jun. 16, 2023, granted, now 11,857,542, issued on Jan. 2, 2024.
Application 18/440,217 is a continuation in part of application No. 18/137,925, filed on Apr. 21, 2023.
Application 18/210,719 is a continuation of application No. 17/559,177, filed on Dec. 22, 2021, granted, now 11,717,515, issued on Aug. 8, 2023.
Application 18/137,925 is a continuation of application No. 17/110,398, filed on Dec. 3, 2020, granted, now 11,925,709, issued on Mar. 12, 2024.
Application 17/110,398 is a continuation of application No. 16/178,641, filed on Nov. 2, 2018, abandoned.
Application 16/178,641 is a continuation of application No. 15/115,026, granted, now 10,117,836, issued on Nov. 6, 2018, previously published as PCT/US2015/013672, filed on Jan. 30, 2015.
Claims priority of provisional application 63/129,379, filed on Dec. 22, 2020.
Claims priority of provisional application 62/087,366, filed on Dec. 4, 2014.
Claims priority of provisional application 61/936,019, filed on Feb. 5, 2014.
Prior Publication US 2025/0177365 A1, Jun. 5, 2025
1. A rapid-release pharmaceutical tablet comprising:
(i) an amorphous compound of formula Ia:
wherein each of Rb is hydrogen, and
(ii) a disintegration system,
wherein when said tablet is subjected to a dissolution test complying with USP 30 NF25 Chapt. 711, said tablet releases at least about 90% of the compound of Formula Ia contained therein in less than about 20 minutes.
